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DOPEXAMINE

Catalog No. T8653 CAS 86197-47-9

Dopexamine is a dopaminergic agonist

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DOPEXAMINE, CAS 86197-47-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 133.00
2 mg	In stock	$ 198.00
5 mg	In stock	$ 298.00
10 mg	In stock	$ 453.00
25 mg	In stock	$ 747.00
50 mg	In stock	$ 1,050.00
100 mg	In stock	$ 1,420.00
1 mL * 10 mM (in DMSO)	In stock	$ 323.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Dopexamine is a dopaminergic agonist

In vivo

Dopexamine hydrochloride has interesting vasodilator properties, with marked intrinsic agonist activity at beta-2 adrenoreceptors and a lesser agonist activity at dopaminergic receptors (DA1 and DA2).?Dopexamine hydrochloride is responsible for an inhibition of neuronal re-uptake of catecholamines (uptake-1), producing an indirect stimulation of cardiac beta 1-receptors.?Dopexamine hydrochloride improves cardiac performance by a marked vasodilation and a mild inotropic activity.?The specific activity at dopaminergic receptors increases cerebral, myocardial, splanchnic and renal blood flows.?These haemodynamic effects are associated with an increase in diuresis and natriuresis.?These benefits are achieved without side effects such as an increased myocardial oxygen consumption, although induced tachycardia may be responsible for chest pain/anginae pain in patients with ischaemic heart disease[1].

Molecular Weight	356.5
Formula	C22H32N2O2
CAS No.	86197-47-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (154.28 mM)

References and Literature

1. Perrin G , Papazian L , Martin C . [Dopexamine: a new dopaminergic agonist].[J]. Ann Fr Anesth Reanim, 1993, 12(3):308-320. 2. Eley K A , Young J D , Watt-Smith S R . Epinephrine, norepinephrine, dobutamine, and dopexamine effects on free flap skin blood flow.[J]. Plastic & Reconstructive Surgery, 2012, 130(3):564. 3. Napoleone P , Ricci A , Ferrante F , et al. Dopexamine hydrochloride in the human heart: receptor binding and effects on cAMP generation[J]. European Heart Journal, 1993, 13(12):1709-1717.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Neurotransmitter Receptor Compound Library ReFRAME Related Library Antidepressant Compound Library Human Metabolite Library Bioactive Compounds Library Max

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Keywords

DOPEXAMINE 86197-47-9 GPCR/G Protein Neuroscience Dopamine Receptor inhibitor inhibit

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