Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DOV-216,303 Free Base (DOV-216303) is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 135.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 428.00 | |
25 mg | In stock | $ 686.00 | |
50 mg | In stock | $ 969.00 | |
100 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 343.00 |
Description | DOV-216,303 Free Base (DOV-216303) is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects. |
Targets&IC50 | Norepinephrine:20 nM , Dopamine:78 nM , 5-HT:14 nM |
In vivo | In male Sprague Dawley rats of OBX or Sham surgery, DOV 216,303 (20 mg/kg; i.p.; choronic) increases extracellular concentrations of dopamine, norepinephrine and serotonin and significantly increases extracellular baseline serotonin concentrations while DOV-216,303 (20 mg/kg; i.p.; acute) significantly increases dopamine, norepinephrine and serotonin levels[2]. |
Synonyms | DOV-216303 |
Molecular Weight | 228.12 |
Formula | C11H11Cl2N |
CAS No. | 66504-40-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (547.96 mM)
Ethanol: 95 mg/mL (416.45 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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DOV-216,303 Free Base 66504-40-3 GPCR/G Protein Neuroscience Serotonin Transporter Dopamine Receptor Norepinephrine inhibit SLC6A4 DOV 216303 DOV 216,303 Free Base 5-HTT DAT DOV216303 SERT Dopamine Transporter SLC6A3 Inhibitor DOV-216,303 DOV216,303 Free Base DOV-216303 inhibitor