Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 135.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 455.00 | |
25 mg | In stock | $ 753.00 | |
50 mg | In stock | $ 1,060.00 | |
100 mg | In stock | $ 1,430.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 296.00 |
Description | DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects. |
Targets&IC50 | Nav1.7 (human):22.8 nM, Nav1.7 (mouse):59.4 nM |
In vitro | DS-1971a showed high NaV1.7 inhibitory potency in vitro. The IC50 values are of 22.8 nM for hNaV1.7 and 59.4 mM for mNaV1.7[1]. |
In vivo | DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice with ED50 of 0.32 mg/kg[1]. |
Molecular Weight | 465.93 |
Formula | C20H21ClFN5O3S |
CAS No. | 1450595-86-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (214.62 mM)
You can also refer to dose conversion for different animals. More
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DS-1971a 1450595-86-4 Membrane transporter/Ion channel Sodium Channel hypersensitivity thermal hyperalgesia Na channels inhibit Na+ channels Inhibitor toxicity DS 1971a DS1971a mechanical inhibitor