Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DS18561882 also inhibited MTHFD1 (IC50=0.57).DS18561882 had good oral drug kinetics.DS18561882 is a potent isozyme-selective methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with IC50 value of 0.0063.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 242.00 | |
5 mg | 5 days | $ 297.00 | |
25 mg | 6-8 weeks | $ 987.00 | |
50 mg | 6-8 weeks | $ 1,360.00 | |
100 mg | 6-8 weeks | $ 1,860.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 476.00 |
Description | DS18561882 also inhibited MTHFD1 (IC50=0.57).DS18561882 had good oral drug kinetics.DS18561882 is a potent isozyme-selective methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with IC50 value of 0.0063. |
Targets&IC50 | MTHFD2:0.0063 μM , MTHFD1:0.57 μM |
In vitro | DS18561882 (0-150 nM) gives the lowest GI50 value (140 nM) against the MDA-MB-231 cell line. |
In vivo | DS18561882 (oral;10mg /kg, 30mg /kg, 100mg /kg or 300mg /kg) had good oral drug kinetics, including ACU(64.6, 264, 726ug. H /ml).;Cmax (11.4, 56.5, 90.1 ° g/ml).T1/2 (2.21, 2.16, 2.32 hours) at 30 mg/kg;100 mg/kg;200 mg/kg, respectively.DS18561882 was suspended in 0.5% (W/V) methyl cellulose 400 solution.DS18561882 (oral;30, 100 or 300 mg/kg;Tumor growth inhibition was inhibited in a dose-dependent manner and was completely inhibited in mice at a dose of 300 mg/kg (TGI: 67%). |
Molecular Weight | 608.63 |
Formula | C28H31F3N4O6S |
CAS No. | 2227149-22-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (410.76 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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DS18561882 2227149-22-4 Others DS-18561882 DS 18561882 inhibitor inhibit