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Danicamtiv

Catalog No. T15050 CAS 1970972-74-7

Synonyms: MYK-491, SAR 440181

Danicamtiv (MYK-491) is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.

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Danicamtiv, CAS 1970972-74-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 138.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 478.00
25 mg	In stock	$ 789.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,480.00
1 mL * 10 mM (in DMSO)	In stock	$ 318.00

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Purity: 99.75%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Danicamtiv (MYK-491) is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.

Synonyms	MYK-491, SAR 440181
Molecular Weight	435.42
Formula	C16H20F3N5O4S
CAS No.	1970972-74-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (114.83 mM), Sonification is recommended.

References and Literature

1. Sarah Fernandes, et al. Abstract 15707: MYK-491, a Novel Small-Molecule Cardiac Myosin Activator Increases Cardiac Systolic Function and Preserves Mechanical Efficiency: Pre-Clinical in vivo and in vitro Evidence. Circulation. 2019;140:A15707 2. Johan Oslob, et al. 4-methylsulfonyl-substituted piperidine urea compounds for the treatment of dilated cardiomyopathy (dcm). WO2016118774A1.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Clinical Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compounds Library Max Bioactive Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

BTS JB061 JB062 16-38-Thymosin β4 (cattle) (TFA) Phenamacril Omecamtiv mecarbil ML-7 hydrochloride HA-100

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Danicamtiv 1970972-74-7 Cytoskeletal Signaling Myosin Inhibitor allosteric MYK-491 cardiac function inhibit SAR-440181 acto-myosin inotropic SAR440181 SAR 440181 systolic MYK 491 MYK491 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.