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Dapiprazole Hydrochloride

Catalog No. T3996   CAS 72822-13-0
Synonyms: Glamidolo Hydrochloride, Reversil Hydrochloride

Dapiprazole Hydrochloride (Glamidolo Hydrochloride) is an alpha-1-adrenergic antagonist that acts by blocking alpha-adrenergic receptors in the smooth muscle of blood vessels (arteries, arterioles and veins), gastrointestinal tract, and radial smooth muscle of the iris.

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Dapiprazole Hydrochloride Chemical Structure
Dapiprazole Hydrochloride, CAS 72822-13-0
Pack Size Availability Price/USD Quantity
10 mg In stock $ 43.00
25 mg In stock $ 89.00
50 mg In stock $ 137.00
100 mg In stock $ 197.00
200 mg In stock $ 297.00
1 mL * 10 mM (in DMSO) In stock $ 30.00
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Purity: 100%
Purity: 99.86%
Purity: 99.86%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dapiprazole Hydrochloride (Glamidolo Hydrochloride) is an alpha-1-adrenergic antagonist that acts by blocking alpha-adrenergic receptors in the smooth muscle of blood vessels (arteries, arterioles and veins), gastrointestinal tract, and radial smooth muscle of the iris.
In vivo Sixty normal male and female volunteers between 18 and 40 years of age were recruited for a double-masked, placebo-controlled, crossover study in which each eye of each subject was dilated with 2.5% phenylephrine. After one hour, one eye was treated with 0.5% dapiprazole, and the contralateral eye was treated with placebo.
Synonyms Glamidolo Hydrochloride, Reversil Hydrochloride
Molecular Weight 361.92
Formula C19H28ClN5
CAS No. 72822-13-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31 mg/mL

TargetMolReferences and Literature

1. Hogan TS., et al. Dose-response study of dapiprazole HCl in the reversal of mydriasis induced by 2.5% phenylephrine. J Ocul Pharmacol Ther. 1997 Aug;13(4):297-302 2. Silvestrini B., et al. Psychopharmacological profile of dapiprazole, a new potential antipsychotic agent. Arzneimittelforschung. 1982;32(6):668-73. 3. Lisciani R., et al. General pharmacological properties of dapiprazole, a potential psychotropic agent. Arzneimittelforschung. 1982;32(6):674-8. 4. Silvestrini B., et al. Effects of dapiprazole on pupillary size and intraocular pressure in rabbits. Arzneimittelforschung. 1982;32(6):678-81. 5. Connor CG., et al. The clinical efficacy of Rev-Eyes in reversing the effects of pupillary dilation. J Am Optom Assoc. 1993 Sep;64(9):634-6.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Hypertension Compound Library Endocrinology-Hormone Compound Library NO PAINS Compound Library GPCR Compound Library Anti-Alzheimer's Disease Compound Library Anti-Cardiovascular Disease Compound Library Coagulation and Anticoagulation Compound Library

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Keywords

Dapiprazole Hydrochloride 72822-13-0 GPCR/G Protein Neuroscience Adrenergic Receptor opioid withdrawal Glamidolo Hydrochloride Inhibitor Beta Receptor inhibit mydriasis Dapiprazole Reversil Hydrochloride inhibitor

 

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