Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 79.00 | |
10 mg | In stock | $ 116.00 | |
25 mg | In stock | $ 188.00 | |
50 mg | In stock | $ 261.00 | |
100 mg | In stock | $ 353.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 87.00 |
Description | Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. |
Targets&IC50 | HIV reverse transcriptase:24 nM |
In vivo | Dapivirine-containing gel at vaginal level inhibits cell-associated HIV infection in mice. [3] More placebo (7 of 12) than Dapivirine (3 of 24) gel users has positive vaginal swab results, with white blood cells being the most common finding. Dapivirine (0.05%) results in Cmax of 715 pg/mL, AUC of 15 ng×h/mL and T1/2 of 89.87 hours in plasma after 14 days post-dose. Mean Dapivirine (0.05%) concentrations in vaginal fluids collected at the introitus, mid vagina, and cervix are in the range of 62-265 μg/g on day 1. [4] |
Synonyms | R147681, TMC120 |
Molecular Weight | 329.4 |
Formula | C20H19N5 |
CAS No. | 244767-67-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 32 mg/mL (97.1 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Dapivirine 244767-67-7 Apoptosis Autophagy Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase TMC-120 Inhibitor R147681 R-147681 inhibit TMC120 TMC 120 HIV Human immunodeficiency virus R 147681 inhibitor