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Darglitazone

Catalog No. T22708 CAS 141200-24-0

Synonyms: CP-86325

Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid metabolism.

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Darglitazone, CAS 141200-24-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 147.00
25 mg	In stock	$ 248.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 543.00

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Purity: 99.19%

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Description	Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid metabolism.
In vitro	In cell lines representing white (3T3-L1 and 3T3-F442A) and brown (HIB-1B) adipose tissues and skeletal muscle (L6), Darglitazone(30 μM) stimulated the expression of UCP2 gene probably via PPAR-γ and increased uncoupling protein 2 (UCP2) mRNA[1].
In vivo	In male diabetic ob/ob mice, Darglitazone dramatically reduces the infarct size in the ob/ob mice at 24?h of recovery. Normalized blood glucose and reduced circulating triglycerides (TG) and very-low-density lipoproteins (VLDL) in diabetic ob/ob mice without having any effect in the nondiabetic mice. Darglitazone treatment restores acute cerebral inflammatory responses that were absent in the diabetic mice and profoundly improved their recovery from hypoxic-ischemic (H/I) insult[2].

Synonyms	CP-86325
Molecular Weight	420.48
Formula	C23H20N2O4S
CAS No.	141200-24-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20mg/ml

Ethanol: ≤ 5 mg/mL

References and Literature

1. A Camirand, et al. Thiazolidinediones stimulate uncoupling protein-2 expression in cell lines representing white and brown adipose tissues and skeletal muscle. Endocrinology. 1998 Jan;139(1):428-31. 2. Rashmi Kumari, et al. The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse. J Cereb Blood Flow Metab. 2010 Feb;30(2):352-60.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Obesity Compound Library Metabolism Compound Library Anti-Breast Cancer Compound Library ReFRAME Related Library Anti-Cancer Compound Library Transcription Factor-Targeted Compound Library Orally Active Compound Library DNA Damage & Repair Compound Library Anti-Pancreatic Cancer Compound Library Nuclear Receptor Compound Library

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Keywords

Darglitazone 141200-24-0 DNA Damage/DNA Repair Metabolism PPAR oral UCP2 corticosterone CP-86325 PPAR-γ Diabetes CP86325 Inhibitor inhibit Peroxisome proliferator-activated receptors thiazolidinedione CP 86325 inhibitor

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