Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dasotraline hydrochloride (SEP-225289 hydrochloride) (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 41.00 | |
10 mg | In stock | $ 66.00 | |
25 mg | In stock | $ 98.00 | |
50 mg | In stock | $ 148.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | Dasotraline hydrochloride (SEP-225289 hydrochloride) (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. |
Targets&IC50 | norepinephrine:6nM, dopamine:4nM, erotonin transporters:11 nM |
In vivo | Acute administration of dasotraline dose-dependently decreases the spontaneous firing rate of LC NE, VTA DA and DR 5-HT neurons through the activation of α2, D2 and 5-HT1A autoreceptors, respectively. Dasotraline predominantly inhibits the firing rate of LC NE neurons while producing only a partial decrease in VTA DA and DR 5-HT neuronal discharge. SEP-225289 is equipotent at inhibiting 5-HT and NE transporters because it prolongs to the same extent the time required for a 50% recovery of the firing activity of dorsal hippocampus CA3 pyramidal neurons from the inhibition induced by microiontophoretic application of 5-HT and NE[1]. Average dopamine and serotonin transporter occupancies increase with increasing doses of SEP-225289. Average dopamine and serotonin transporter occupancies are 33%±11% and 2%±13%, respectively, for 8 mg; 44%±4% and 9%±10%, respectively, for 12 mg; and 49%±7% and 14%±15%, respectively, for 16 mg[2]. |
Synonyms | SEP-225289 hydrochloride |
Molecular Weight | 328.66 |
Formula | C16H16Cl3N |
CAS No. | 675126-08-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31 mg/mL (94.32 mM)
You can also refer to dose conversion for different animals. More
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Dasotraline hydrochloride 675126-08-6 GPCR/G Protein Neuroscience Dopamine Receptor Serotonin Transporter 5-HT Receptor Norepinephrine Dasotraline Dopamine Transporter inhibit Dasotraline Hydrochloride Inhibitor SERT SEP-225289 SEP 225289 Hydrochloride SEP225289 Hydrochloride SLC6A4 SEP 225289 5-HTT DAT SEP225289 SLC6A3 SEP-225289 hydrochloride SEP-225289 Hydrochloride inhibitor