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Decursinol angelate

Catalog No. TN1557 CAS 130848-06-5

Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion and inflammatory activation of cancer cells through modulation of PI3K/AKT, ERK and NF-kappaB, its anti-inflammatory activity may contribute to its anti-cancer activity.

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Decursinol angelate, CAS 130848-06-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 249.00
50 mg	In stock	$ 373.00
100 mg	In stock	$ 552.00
1 mL * 10 mM (in DMSO)	In stock	$ 93.00

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Purity: 99.65%

Biological Description

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Storage & Solubility Information

Description	Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion and inflammatory activation of cancer cells through modulation of PI3K/AKT, ERK and NF-kappaB, its anti-inflammatory activity may contribute to its anti-cancer activity.
In vitro	Here, we show that treatment with these compounds improves wound healing by HaCaT human keratinocytes. Wound healing was increased by treatment with up to a threshold concentration of decursin, Decursinol angelate, a mixture of both, and a nano-emulsion of these compounds, but inhibited by treatment with higher concentrations. Immunoblotting and fluorescence imaging of cells expressing an epidermal growth factor receptor (EGFR) biosensor demonstrated that these compounds did not stimulate wound healing by inducing EGFR phosphorylation. Rather, transcriptional analysis revealed that decursin and Decursinol angelate improved wound healing by upregulating the expression of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors.
Source	Natural Products > Apiaceae > Angelica

Molecular Weight	328.36
Formula	C19H20O5
CAS No.	130848-06-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/mL (197.95 mM)

References and Literature

1. Decursin and decursinol angelate improve wound healing by upregulating transcription of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors in human keratinocytes.Biochem Biophys Res Commun. 2018 May 23;499(4):979-984.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Kinase Inhibitor Library Anti-Neurodegenerative Disease Compound Library Traditional Chinese Medicine Monomer Library Tyrosine Kinase Inhibitor Library TGF-beta/Smad Compound Library Anti-Cancer Active Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Pyroptosis Compound Library Anti-Pancreatic Cancer Compound Library

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Keywords

Decursinol angelate 130848-06-5 Angiogenesis Chromatin/Epigenetic Cytoskeletal Signaling MAPK Tyrosine Kinase/Adaptors ERK VEGFR PKC JNK Protein kinase C inhibit Inhibitor inhibitor

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