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Deferasirox

Catalog No. T1457 CAS 201530-41-8

Synonyms: ICL 670, CGP-72670

Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Deferasirox, CAS 201530-41-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 61.00
25 mg	In stock	$ 79.00
50 mg	In stock	$ 119.00
100 mg	In stock	$ 173.00
500 mg	In stock	$ 429.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.89%

Purity: 99.4%

Biological Description

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Storage & Solubility Information

Description	Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.
In vitro	Orally administered Deferasirox in rats achieves an absorption rate of at least 75% with a bioavailability of 26%. Monotherapy with Deferasirox modestly increases the survival time in IPA mice. When administered, either intravenously or orally, Deferasirox mainly circulates in the blood as its unaltered form and its iron complex, with a 99.2% binding rate to plasma proteins. Deferasirox significantly enhances survival rates and reduces tissue fungal burden in mice with diabetic ketoacidosis or neutropenia suffering from mucormycosis, showing effects comparable to those of liposomal Amphotericin B. Additionally, Deferasirox bolsters the host inflammatory response against mucormycosis. The combined use of Deferasirox and liposomal Amphotericin B synergistically improves survival rates and decreases fungal load in tissues affected by mucormycosis.
In vivo	Deferasirox exhibits antifungal activity against Aspergillus with MIC (Minimum Inhibitory Concentration) and MFC (Minimum Fungicidal Concentration) values of 25 and 50 mg/L, respectively. It effectively chelates iron ions from Rhizopus species, showing antiviral activity in vitro against 28 out of 29 Mucorales clinical isolates at concentrations much lower than those achievable in clinical serum levels. Deferasirox significantly inhibits the activity of NF-κB by chelating its active subunit p65 in an inactive form within the cytoplasm in 28 out of 40 peripheral blood samples. Additionally, it inhibits three human myeloid cell lines (K562, U937, and HL60) with IC50 values ranging from 17 to 50 mM.
Cell Research	Deferasirox is dissolved in DMSO. HL-60 or KG-1 cells are treated with 0, 5, 10, 50 μM of deferasirox for 24 or 48 h, and proliferation is determined by an MTT assay[2].

Synonyms	ICL 670, CGP-72670
Molecular Weight	373.36
Formula	C21H15N3O4
CAS No.	201530-41-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 69 mg/mL (184.8 mM)

Ethanol: 2 mg/mL (5.35 mM)

References and Literature

1. Ibrahim AS, et al. J Clin Invest, 2007, 117(9), 2649-2657. 2. Messa E, et al. Haematologica, 2010, 95(8), 1308-1316. 3. Ohyashiki JH, et al. Cancer Sci, 2009, 100(5), 970-977. 4. Bruin GJ, et al. Drug Metab Dispos, 2008, 36(12), 2523-2538. 5. Ibrahim AS, et al. J Antimicrob Chemother, 2010, 65(2), 289-292. 6. Sobbe A, et al. Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox. J Gastroenterol Hepatol. 2015 Mar;30(3):638-45.

Citations

1. Cui P, Liu T, Sheng Y, et al.Identification and validation of ferroptosis-related lncRNAs signature in intervertebral disc degeneration.Gene.2024: 148381.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library EMA Approved Drug Library Bioactive Compound Library Anti-Aging Compound Library Anti-Metabolism Disease Compound Library FDA-Approved & Pharmacopeia Drug Library Target-Focused Phenotypic Screening Library NO PAINS Compound Library Cell Cycle Compound Library Pediatric Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Deferasirox 201530-41-8 Apoptosis Microbiology/Virology Others Ferroptosis Antibacterial Bacterial chelator ICL 670 transfusional Inhibitor CGP72670 inhibit CGP-72670 available ICL-670 CGP 72670 overload iron orally ICL670 inhibitor

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