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Dehydropachymic acid

Catalog No. TN1563 CAS 77012-31-8

Dehydropachymic acid shows antiinflammatory activity.

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Dehydropachymic acid, CAS 77012-31-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 139.00
5 mg	In stock	$ 392.00
10 mg	In stock	$ 595.00
25 mg	In stock	$ 949.00
50 mg	In stock	$ 1,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 487.00

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Purity: 99.61%

Purity: 98.22%

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Description	Dehydropachymic acid shows antiinflammatory activity.
In vitro	Here, we show that a characterized mixture of triterpenes extracted from P. cocos (PTE) and three purified triterpenes: pachymic acid (PA), Dehydropachymic acid (DPA) and polyporenic acid C (PPAC) suppress the proliferation of the human pancreatic cancer cell lines Panc-1, MiaPaca-2, AsPc-1 and BxPc-3. Moreover, the most effective compound, PA, only slightly affects the proliferation of HPDE-6 normal pancreatic duct epithelial cells. The anti-proliferative effects of PTE on BxPc-3 cells are mediated by the cell cycle arrest at G0/G1 phase. DNA microarray analysis demonstrated that PTE significantly downregulates the expression of KRAS and matrix metalloproteinase-7 (MMP-7) in BxPc-3 cells. In addition, PTE and PA suppress the invasive behavior of BxPc-3 cells. The inhibition of invasiveness by PTE and PA was associated with the reduction of MMP-7 at the protein level and the role of MMP-7 further confirmed by the gene silencing of MMP-7 which also suppressed the invasiveness of BxPc-3 cells.
Source	Natural Products > Polyporaceae > Wolfiporia

Molecular Weight	526.75
Formula	C33H50O5
CAS No.	77012-31-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.27 mg/mL (10 mM)

References and Literature

1. Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7.Int J Oncol. 2013 Jun;42(6):1869-74.

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Terpene Natural Product Library Natural Product Library Selected Plant-Sourced Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Food as Medicine Compound Library Anti-Tumor Natural Product Library Chinese Pharmacopoeia Natural Product Library Traditional Chinese Medicine Monomer Library Natural Product Library for HTS

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Keywords

Dehydropachymic acid 77012-31-8 Autophagy Immunology/Inflammation Immunology/Inflammation related inhibit Inhibitor inhibitor

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