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Delphinidin chloride

Catalog No. TN1567 CAS 528-53-0

Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in vascular relaxation. At the dose of 1-40 μM, epithelial growth factor receptor signaling and estrogen receptor α expression were inhibited, which was associated with apoptosis and autophagy. Delphinidin chloride regulates JAK/STAT3 and MAPKinase signaling. Delphinidin also inhibited the histone acetyltransferase activity of p300/CBP (IC50 was about 30 μM).

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Delphinidin chloride, CAS 528-53-0

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Description	Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in vascular relaxation. At the dose of 1-40 μM, epithelial growth factor receptor signaling and estrogen receptor α expression were inhibited, which was associated with apoptosis and autophagy. Delphinidin chloride regulates JAK/STAT3 and MAPKinase signaling. Delphinidin also inhibited the histone acetyltransferase activity of p300/CBP (IC50 was about 30 μM).
In vitro	It also inhibits signaling through epithelial growth factor receptors, suppressing the expression of estrogen receptor α and inducing both apoptosis and autophagy at a dose of 1-40 μM.[1][2]
In vivo	The effects of IdB 1056 observed in vivo at the microcirculatory level prevent the injury to endothelial cell function associated with diabetes and/or oxidative stress.[3]
Source	Natural Products > Ericaceae > Vaccinium

Molecular Weight	338.7
Formula	C15H11ClO7
CAS No.	528-53-0

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 56.2 mg/mL (166.1 mM), Sonification is recommended.

References and Literature

1. Ozbay T, et al. Delphinidin Inhibits HER2 and Erk1/2 Signaling and Suppresses Growth of HER2-Overexpressing and Triple Negative Breast Cancer Cell Lines. Breast Cancer (Auckl). 2011;5:143-154. 2. Aiyer HS, et al. Influence of berry polyphenols on receptor signaling and cell-death pathways: implications for breast cancer prevention. J Agric Food Chem. 2012;60(23):5693-5708. 3. Bertuglia S, et al. Effects of the natural flavonoid delphinidin on diabetic microangiopathy. Arzneimittelforschung. 1995;45(4):481-485. 4. Holton TA, et al. Cloning and expression of cytochrome P450 genes controlling flower colour. Nature. 1993;366(6452):276-279. 5. Seong AR, et al. Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-κB acetylation in fibroblast-like synoviocyte MH7A cells. Biochem Biophys Res Commun. 2011;410(3):581-586.

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Keywords

Delphinidin chloride 528-53-0 Angiogenesis Endocrinology/Hormones Tyrosine Kinase/Adaptors Estrogen Receptor/ERR VEGFR Delphinidin Chloride inhibitor inhibit

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