Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Denifanstat (FASN-IN-2) is a Fatty Acid Synthase (FASN) inhibitor(IC50 of 0.052 μM and an EC50 of 0.072 μM),with potential antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 83.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 332.00 | |
25 mg | In stock | $ 558.00 | |
50 mg | In stock | $ 788.00 | |
100 mg | In stock | $ 1,120.00 | |
500 mg | In stock | $ 2,230.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 228.00 |
Description | Denifanstat (FASN-IN-2) is a Fatty Acid Synthase (FASN) inhibitor(IC50 of 0.052 μM and an EC50 of 0.072 μM),with potential antineoplastic activity. |
Targets&IC50 | FASN:0.052 μM |
In vitro |
TVB-2640 is an orally bioavailable fatty acid synthase (FASN) inhibitor, with potential antineoplastic activity. Upon administration, TVB-2640 binds to and blocks FASN, which prevents the synthesis of palmitate needed for tumor cell growth and survival. This leads to a reduction in cell signaling, an induction of tumor cell apoptosis and the inhibition of cell proliferation in susceptible tumor cells. FASN, an enzyme responsible for the de novo synthesis of palmitic acid, is overexpressed in tumor cells and plays a key role in tumor metabolism, lipid signaling, tumor cell survival and drug resistance; tumor cells are dependent on increased fatty acid production for their enhanced metabolic needs and rapid growth. Check for active clinical trials or closed clinical trials using this agent. |
Synonyms | FASN-IN-2, TVB2640, TVB-2640 |
Molecular Weight | 439.55 |
Formula | C27H29N5O |
CAS No. | 1399177-37-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (568.76 mM)
You can also refer to dose conversion for different animals. More
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Denifanstat 1399177-37-7 Metabolism Fatty Acid Synthase SARS-CoV2 FASN-IN-2 ASC40 Inhibitor spike TVB2640 inhibit ASC 40 TVB-2640 TVB 2640 Fatty Acid Synthase (FASN) protein COVID-19 ASC-40 inhibitor