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Deoxycholic acid

Catalog No. T2965 CAS 83-44-3

Synonyms: Cholorebic, Deoxycholate, Desoxycholic acid, Cholanoic Acid, Cholerebic

Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

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Deoxycholic acid, CAS 83-44-3

Pack Size	Availability	Price/USD
100 mg	In stock	$ 53.00
500 mg	In stock	$ 72.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 99.35%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
In vitro	Deoxycholic acid inhibits miR-21 expression in primary rat hepatocytes in a dose-dependent manner, and increases miR-21 pro-apoptotic target programmed cell death 4 (PDCD4) and apoptosis. Deoxycholic acid decreases NF-κB activity, shown to represent an upstream mechanism leading to modulation of the miR-21/PDCD4 pathway[1].
In vivo	miR-21 expression is down-regulated upon short exposures to Deoxycholic acid, as is the downstream pathway, with concomitant PIDD processing and activation of caspase-2, which contributes to DCA-induced liver damage[1].
Cell Research	Primary rat hepatocytes were isolated from male rats (100 to 150 g) by collagenase perfusion. After isolation, hepatocytes were resuspended in complete Williams E medium and plated on BD Primaria™ culture dishes at 5 × 104 cells/cm2. Cells are kept at 37 °C in a humidified atmosphere of 5% CO2 for 4-6 h to allow attachment. Plates are then washed with phosphate buffered saline (PBS) 1× in order to remove dead cells and incubated in Williams E medium supplemented with 25 to 200 μM DCA or no addition (control) for 24 h. Primary rat hepatocytes are processed for total RNA and protein isolation, cell viability, cytotoxicity and caspase activity assays and Hoechst staining. (Only for Reference)

Synonyms	Cholorebic, Deoxycholate, Desoxycholic acid, Cholanoic Acid, Cholerebic
Molecular Weight	392.57
Formula	C24H40O4
CAS No.	83-44-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 72 mg/mL (183.4 mM)

Ethanol: 56 mg/mL (142.6 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Pedro M. Rodrigues, et al. Sci Rep. 2015, 5:17528.

Citations

1. Yan Y, Niu Z, Sun C, et al. Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism. Nature Communications. 2022, 13(1): 1-16.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Microbial Natural Product Library Drug Repurposing Compound Library GPCR Compound Library Anti-Cancer Active Compound Library Human Endogenous Metabolite Library Anti-Obesity Compound Library Bioactive Compounds Library Max

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Keywords

Deoxycholic acid 83-44-3 GPCR/G Protein Metabolism GPCR19 Endogenous Metabolite TGR5 Cholorebic G-protein coupled receptor 19 G protein-coupled Bile Acid Receptor 1 GPBAR1 Deoxycholate G protein-coupled bile acid receptor bile acid Desoxycholic acid inhibit Cholanoic Acid Inhibitor Cholerebic inhibitor

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