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Desfesoterodine

Catalog No. T6364   CAS 207679-81-0
Synonyms: 5-HMT, (R)-5-Hydroxymethyl Tolterodine, PNU-200577, 5-HM, 5-hydroxymethyl Tolterodine

Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM.

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Desfesoterodine Chemical Structure
Desfesoterodine, CAS 207679-81-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 60.00
5 mg In stock $ 147.00
10 mg In stock $ 228.00
25 mg In stock $ 392.00
50 mg In stock $ 578.00
100 mg In stock $ 833.00
500 mg In stock $ 1,690.00
1 mL * 10 mM (in DMSO) In stock $ 162.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
Targets&IC50 mAChR:0.84 nM(Kb)
In vitro 5-hydroxymethyl tolterodine is a major pharmacologically active metabolite of tolterodine. 5-hydroxymethyl tolterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips. 5-hydroxymethyl tolterodine antagotizes muscarinic receptors with a pA2 of 9.1. 5-hydroxymethyl tolterodine causes a concentration-dependent inhibition of (-)3 H-QNB binding in homogenates of guinea-pig urinary bladder, parotid gland, heart and cerebral cortex. [1] 5-hydroxymethyl tolterodine has a similar pharmacological profile with tolterodine. [2] Intravenous infusion of 5-hydroxymethyl tolterodine produces a dose-dependent inhibition of the intravesical volume-induced urinary bladder contraction measured as the micturition pressure. [3]
In vivo 5-hydroxymethyl tolterodine is significantly more potent at inhibiting acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50 15 and 40 nmol/kg, respectively. 5-hydroxymethyl tolterodine is three times more potent at the urinary bladder compared to the salivary gland. [1]
Synonyms 5-HMT, (R)-5-Hydroxymethyl Tolterodine, PNU-200577, 5-HM, 5-hydroxymethyl Tolterodine
Molecular Weight 341.49
Formula C22H31NO2
CAS No. 207679-81-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 63 mg/mL (184.5 mM)

DMSO: 63 mg/mL (184.5 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Nilvebrant L, et al. Pharmacol Toxicol, 1997, 81(4), 169-172. 2. Nilvebrant L, et al. Life Sci, 1997, 60(13-14), 1129-1136. 3. Modiri AR, et al. Urology, 2002, 59(6), 963-968.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Human Metabolite Library Neurotransmitter Receptor Compound Library Bioactive Compound Library Preclinical Compound Library Neuronal Signaling Compound Library Inhibitor Library

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Keywords

Desfesoterodine 207679-81-0 Neuroscience AChR Muscarinic acetylcholine receptor 5-HMT metabolite PNU-200583 Fesoterodine inhibit (R)-5-Hydroxymethyl Tolterodine receptor PNU200577 Tolterodine muscarinic pA2 PNU-200577 5-HM Inhibitor PNU 200577 mAChR 5-Hydroxymethyl Tolterodine 5-hydroxymethyl Tolterodine inhibitor

 

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