Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 60.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 228.00 | |
25 mg | In stock | $ 392.00 | |
50 mg | In stock | $ 578.00 | |
100 mg | In stock | $ 833.00 | |
500 mg | In stock | $ 1,690.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 162.00 |
Description | Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM. |
Targets&IC50 | mAChR:0.84 nM(Kb) |
In vitro | 5-hydroxymethyl tolterodine is a major pharmacologically active metabolite of tolterodine. 5-hydroxymethyl tolterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips. 5-hydroxymethyl tolterodine antagotizes muscarinic receptors with a pA2 of 9.1. 5-hydroxymethyl tolterodine causes a concentration-dependent inhibition of (-)3 H-QNB binding in homogenates of guinea-pig urinary bladder, parotid gland, heart and cerebral cortex. [1] 5-hydroxymethyl tolterodine has a similar pharmacological profile with tolterodine. [2] Intravenous infusion of 5-hydroxymethyl tolterodine produces a dose-dependent inhibition of the intravesical volume-induced urinary bladder contraction measured as the micturition pressure. [3] |
In vivo | 5-hydroxymethyl tolterodine is significantly more potent at inhibiting acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50 15 and 40 nmol/kg, respectively. 5-hydroxymethyl tolterodine is three times more potent at the urinary bladder compared to the salivary gland. [1] |
Synonyms | 5-HMT, (R)-5-Hydroxymethyl Tolterodine, PNU-200577, 5-HM, 5-hydroxymethyl Tolterodine |
Molecular Weight | 341.49 |
Formula | C22H31NO2 |
CAS No. | 207679-81-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 63 mg/mL (184.5 mM)
DMSO: 63 mg/mL (184.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Desfesoterodine 207679-81-0 Neuroscience AChR Muscarinic acetylcholine receptor 5-HMT metabolite PNU-200583 Fesoterodine inhibit (R)-5-Hydroxymethyl Tolterodine receptor PNU200577 Tolterodine muscarinic pA2 PNU-200577 5-HM Inhibitor PNU 200577 mAChR 5-Hydroxymethyl Tolterodine 5-hydroxymethyl Tolterodine inhibitor