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Dexamethasone Phosphate disodium

Catalog No. T0947L   CAS 2392-39-4
Synonyms: EGP-437, EGP437. Dex-Phos, EGP 437

Dexamethasone Phosphate disodium (EGP437. Dex-Phos) is a water-soluble form of the synthetic glucocorticoid dexamethasone.

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Dexamethasone Phosphate disodium Chemical Structure
Dexamethasone Phosphate disodium, CAS 2392-39-4
Pack Size Availability Price/USD Quantity
50 mg In stock $ 30.00
100 mg In stock $ 41.00
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Purity: 99.88%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dexamethasone Phosphate disodium (EGP437. Dex-Phos) is a water-soluble form of the synthetic glucocorticoid dexamethasone.
In vitro Dexamethasone regulates multiple transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, resulting in the activation and repression of key genes involved in the inflammatory response[1]. Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM. Dexamethasone (EC50=36 nM) induces transcription of the β2-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC50=0.5 nM) inhibits a 3×κB (NF-κB, IκBα, and I-κBβ), which is associated with inhibition of GM-CSF release.
In vivo Treatment with Dexamethasone at a dose of 2×5 mg/kg efficiently inhibits lipopolysaccharide (LPS)-induced inflammation. In our experimental system, treatment with a single dose of Dexamethasone 10 mg/kg (i.p.) markedly decreases the recruitment of granulocytes and spontaneous production of oxygen radicals compared with animals expose to LPS and injected with solvent alone (saline). The effects are statistically significant when administered both 1 h before and 1 h after inhalation of LPS. The number of granulocytes in BALF decreased to levels comparable to healthy animals (given an aerosol of water)[3]. Rats treated with Dexamethasone consume less food and weighed less than control rats. Treated rats also weigh less than pair-fed animals though their food intake is similar. Five days of Dexamethasone injection result in a significant increase in both the liver mass (+42%) and the liver to body weight ratio (+65%). The wet weight of gastrocnemius muscle decreases 20% after 5 days of treatment, but it remains unaffected relative to body weight (g/100 g body weight), indicating that muscle weight loss paralleled body weight loss.
Synonyms EGP-437, EGP437. Dex-Phos, EGP 437
Molecular Weight 516.4
Formula C22H28FNa2O8P
CAS No. 2392-39-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 100 mg/mL (193.65 mM)

DMSO: 1 mg/mL (1.94 mM), ultrasonic and warming and heat to 80°C

TargetMolReferences and Literature

1. Torres MP, Entwistle F, Coote PJ. Effective immunosuppression with dexamethasone phosphate in the Galleria mellonella larva infection model resulting in enhanced virulence of Escherichia coli and Klebsiella pneumoniae. Med Microbiol Immunol. 2016 Aug;205(4):333-43. doi: 10.1007/s00430-016-0450-5. PubMed PMID: 26920133; PubMed Central PMCID: PMC4939170. 2. Patane MA, Schubert W, Sanford T, Gee R, Burgos M, Isom WP, Ruiz-Perez B. Evaluation of ocular and general safety following repeated dosing of dexamethasone phosphate delivered by transscleral iontophoresis in rabbits. J Ocul Pharmacol Ther. 2013 Oct;29(8):760-9. doi: 10.1089/jop.2012.0175. PubMed PMID: 23844757. 3. Martín-Sabroso C, Tavares-Fernandes DF, Espada-García JI, Torres-Suárez AI. Validation protocol of analytical procedures for quantification of drugs in polymeric systems for parenteral administration: dexamethasone phosphate disodium microparticles. Int J Pharm. 2013 Dec 15;458(1):188-96. doi: 10.1016/j.ijpharm.2013.09.026. PubMed PMID: 24120930. 4. Keeler GD, Durdik JM, Stenken JA. Effects of delayed delivery of dexamethasone-21-phosphate via subcutaneous microdialysis implants on macrophage activation in rats. Acta Biomater. 2015 Sep;23:27-37. doi: 10.1016/j.actbio.2015.05.011. PubMed PMID: 25985913.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Bioactive Compound Library Approved Drug Library GPCR Compound Library FDA-Approved & Pharmacopeia Drug Library NO PAINS Compound Library Nuclear Receptor Compound Library Immunology/Inflammation Compound Library

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Keywords

Dexamethasone Phosphate disodium 2392-39-4 Endocrinology/Hormones Glucocorticoid Receptor Dexamethasone Phosphate EGP-437 inhibit Inhibitor Dexamethasone 21-phosphate disodium EGP437. Dex-Phos EGP437 EGP 437 inhibitor

 

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