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Diallyl disulfide

Catalog No. TN1576 CAS 2179-57-9

Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.

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Diallyl disulfide, CAS 2179-57-9

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50 mg	In stock	$ 50.00
100 mg	In stock	$ 73.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 95%

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Description	Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
In vitro	In this study, we evaluated the effects of DADS on airway inflammation using an ovalbumin-induced model of allergic asthma and RAW264.7 cells. DADS decreased nitric oxide production with a reduction in the levels of interleukins (IL)-1β and IL-6 in RAW264.7 cells stimulated with LPS. DADS also reduced the expression of proinflammatory proteins including inducible nitric oxide synthase (iNOS), nuclear factor (NF)-κB, and matrix metalloproteinase (MMP)-9, and it enhanced the expression of antioxidant proteins including Nrf-2 and hemeoxygenase (HO)-1. In in vivo experiments, DADS decreased the inflammatory cell count in the bronchoalveolar lavage fluid (BALF) with IL-4, IL-5, IL-13, and immunoglobulin (Ig) E. These results were consistent with the histological analysis. DADS attenuated the airway inflammation and mucus hypersecretion induced by OVA challenge. In addition, DADS induced the activation of Nrf-2 and the expression of HO-1. In contrast, DADS reduced the activation of NF-κB, iNOS and MMP-9[1]
Source	Natural Products > Amaryllidaceae > Allium

Molecular Weight	146.27
Formula	C6H10S2
CAS No.	2179-57-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.31 mg/mL (50 mM)

References and Literature

1. Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppression.Food Chem Toxicol. 2013 Dec;62:506-13.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Anti-Cancer Active Compound Library Antiparasitic Natural Product Library Natural Product Library for HTS Anti-Lung Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-Breast Cancer Compound Library NO PAINS Compound Library RO5 Drug-like Natural Product Library Human Metabolite Library

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Keywords

Diallyl disulfide 2179-57-9 Immunology/Inflammation NF-Κb IL Receptor NOS NF-κB cholesterol biosynthesis squalene monooxygenase Inhibitor Diallyl Disulfide Diallyl inhibit squalene epoxidation inhibitor

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