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Diethylstilbestrol

Catalog No. T1216 CAS 56-53-1

Synonyms: Stilbestrol, DES

Diethylstilbestrol (DES) is used in the treatment of menopausal and postmenopausal disorders.

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Diethylstilbestrol, CAS 56-53-1

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200 mg	In stock	$ 48.00
1 g	Inquiry	$ 58.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.13%

Purity: 98.67%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Diethylstilbestrol (DES) is used in the treatment of menopausal and postmenopausal disorders.
In vitro	Diethylstilbestrol promotes coactivator release from orphan nuclear receptor ERR beta and inhibits its transcriptional activity in trophoblast stem cells. [1]
In vivo	Diethylstilbestrol treated pregnant mice exhibits abnormal early placenta development associated with an overabundance of trophoblast giant cells and an absence of diploid trophoblast. [1] Diethylstilbestrol causes epigenetic methylation changes that result in persistent alterations in gene expression, leading to tumorigenesis in mouse uterus. Diethylstilbestrol induces c-fos exon-4 hypomethylation at postnatal day 17 in mice uterus, while elevating its mRNA level from postnatal day 5. Diethylstilbestrol exposure leads to hypomethylation in the exon-4 region of c-fos mRNA. [2] Diethylstilbestrol-treated rats exhibits more pronounced delay in maturational development of an adult pattern of immunoexpression of the three proteins compared with GnRHa-treated rats. Diethylstilbestrol results in similar reductions in both Sertoli cell numbers and suppression of testicular growth at 18 and 25 days, though by 35 days the suppression is more pronounced in DES-treated rats. [3] Diethylstilbestrol treatment appears to imprint an abnormal, site-specific demethylation of CpG/-464, which requires ovarian hormones to occur in adult mice. [4] Diethylstilbestrol (2.0 ng/g) per day increases adult prostate weight, whereas a 200 ng/g dose decreases adult prostate weight in male offspring mice. [5]

Synonyms	Stilbestrol, DES
Molecular Weight	268.35
Formula	C18H20O2
CAS No.	56-53-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (186.3 mM)

Ethanol: 50 mg/mL (186.3 mM)

References and Literature

1. Tremblay GB, et al. Genes Dev,2001, 15(7), 833-838. 2. Li S, et al. Mol Carcinog,2003, 38(2), 78-84. 3. Sharpe RM, et al. Biol Reprod,1998, 59(5), 1084-1094. 4. Li S, et al. Cancer Res,1997, 57(19), 4356-4359. 5. vom Saal FS, et al. Proc Natl Acad Sci U S A,1997, 94(5), 2056-2061.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Drug Repurposing Compound Library Nuclear Receptor Compound Library FDA-Approved Drug Library CNS-Penetrant Compound Library Drug-induced Liver Injury (DILI) Compound Library ReFRAME Related Library Orally Active Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Diethylstilbestrol 56-53-1 Endocrinology/Hormones Estrogen/progestogen Receptor Estrogen Receptor/ERR Stilbestrol Inhibitor inhibit DES inhibitor

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