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Endocrinology/Hormones Estrogen/progestogen Receptor Diethylstilbestrol

Diethylstilbestrol

Catalog No. T1216   CAS 56-53-1
Synonyms: Stilbestrol, DES
Purity 98.67% Datasheet MSDS

Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.

Diethylstilbestrol, CAS 56-53-1
Pack Size Availability Price/USD Quantity
10 mg In stock 55.00
25 mg Inquiry 64.00
100 mg Inquiry 80.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.
Targets&IC50 ER,  
In vitro Diethylstilbestrol promotes coactivator release from orphan nuclear receptor ERR beta and inhibits its transcriptional activity in trophoblast stem cells. [1]
In vivo Diethylstilbestrol treated pregnant mice exhibits abnormal early placenta development associated with an overabundance of trophoblast giant cells and an absence of diploid trophoblast. [1] Diethylstilbestrol causes epigenetic methylation changes that result in persistent alterations in gene expression, leading to tumorigenesis in mouse uterus. Diethylstilbestrol induces c-fos exon-4 hypomethylation at postnatal day 17 in mice uterus, while elevating its mRNA level from postnatal day 5. Diethylstilbestrol exposure leads to hypomethylation in the exon-4 region of c-fos mRNA. [2] Diethylstilbestrol-treated rats exhibits more pronounced delay in maturational development of an adult pattern of immunoexpression of the three proteins compared with GnRHa-treated rats. Diethylstilbestrol results in similar reductions in both Sertoli cell numbers and suppression of testicular growth at 18 and 25 days, though by 35 days the suppression is more pronounced in DES-treated rats. [3] Diethylstilbestrol treatment appears to imprint an abnormal, site-specific demethylation of CpG/-464, which requires ovarian hormones to occur in adult mice. [4] Diethylstilbestrol (2.0 ng/g) per day increases adult prostate weight, whereas a 200 ng/g dose decreases adult prostate weight in male offspring mice. [5]

Description

Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.

Targets&IC50

ER

In Vitro

Diethylstilbestrol promotes coactivator release from orphan nuclear receptor ERR beta and inhibits its transcriptional activity in trophoblast stem cells. [1]

In Vivo

Diethylstilbestrol treated pregnant mice exhibits abnormal early placenta development associated with an overabundance of trophoblast giant cells and an absence of diploid trophoblast. [1] Diethylstilbestrol causes epigenetic methylation changes that result in persistent alterations in gene expression, leading to tumorigenesis in mouse uterus. Diethylstilbestrol induces c-fos exon-4 hypomethylation at postnatal day 17 in mice uterus, while elevating its mRNA level from postnatal day 5. Diethylstilbestrol exposure leads to hypomethylation in the exon-4 region of c-fos mRNA. [2] Diethylstilbestrol-treated rats exhibits more pronounced delay in maturational development of an adult pattern of immunoexpression of the three proteins compared with GnRHa-treated rats. Diethylstilbestrol results in similar reductions in both Sertoli cell numbers and suppression of testicular growth at 18 and 25 days, though by 35 days the suppression is more pronounced in DES-treated rats. [3] Diethylstilbestrol treatment appears to imprint an abnormal, site-specific demethylation of CpG/-464, which requires ovarian hormones to occur in adult mice. [4] Diethylstilbestrol (2.0 ng/g) per day increases adult prostate weight, whereas a 200 ng/g dose decreases adult prostate weight in male offspring mice. [5]

Synonyms Stilbestrol, DES
Purity 98.67%
Appearance solid
Molecular Weight 268.35
Formula C18H20O2
CAS No. 56-53-1

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 50 mg/mL (186.3 mM)

Ethanol: 50 mg/mL (186.3 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Tremblay GB, et al. Genes Dev,2001, 15(7), 833-838. 2. Li S, et al. Mol Carcinog,2003, 38(2), 78-84. 3. Sharpe RM, et al. Biol Reprod,1998, 59(5), 1084-1094. 4. Li S, et al. Cancer Res,1997, 57(19), 4356-4359. 5. vom Saal FS, et al. Proc Natl Acad Sci U S A,1997, 94(5), 2056-2061.

Related Compound Libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Neuronal Signaling Compound Library Endocrinology-Hormones Library Hematopoietic Toxicity Compound Library FDA-approved Drug Library GPCR Compound Library CNS-Penetrant Compound Library

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