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Dihydrolipoic acid

Catalog No. T21233 CAS 462-20-4

Synonyms: Reduced thioctic acid, Reduced lipoic acid, DHLA, USAF XR-12, 6,8-Dihydrothioctic acid

Dihydrolipoic acid (USAF XR-12), a dithiol-containing carboxylic acid, acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including peroxynitirite, hydroxyl radicals, hydrogen peroxide, and hypochlorite, at concentrations ranging from 0.01-0.5 mM.

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Dihydrolipoic acid, CAS 462-20-4

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25 mg	In stock	$ 33.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Reduced thioctic acid, Reduced lipoic acid, DHLA, USAF XR-12, 6,8-Dihydrothioctic acid
Molecular Weight	208.34
Formula	C8H16O2S2
CAS No.	462-20-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (239.99 mM)

References and Literature

1. Oláh Z, Vogg ATJ, Kremmer T, Szűcs Z, Varga Z, Dóczi R. Optimization of the reduction of (74)As(V) to (74)As(III) and of the labelling of dithiol dihydrolipoic acid. Appl Radiat Isot. 2019 Jul;149:75-82. doi: 10.1016/j.apradiso.2019.04.004. Epub 2019 Apr 15. PubMed PMID: 31029937. 2. Ren SH, Liu SG, Ling Y, Li NB, Luo HQ. Facile method for iodide ion detection via the fluorescence decrease of dihydrolipoic acid/beta-cyclodextrin protected Ag nanoclusters. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Apr 5;212:199-205. doi: 10.1016/j.saa.2019.01.009. Epub 2019 Jan 4. PubMed PMID: 30639913. 3. Micillo R, Sirés-Campos J, García-Borrón JC, Panzella L, Napolitano A, Olivares C. Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human Tyrosinase. Int J Mol Sci. 2018 Jul 24;19(8). pii: E2156. doi: 10.3390/ijms19082156. PubMed PMID: 30042336; PubMed Central PMCID: PMC6121902. 4. Zhou K, Enkhjargal B, Xie Z, Sun C, Wu L, Malaguit J, Chen S, Tang J, Zhang J, Zhang JH. Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat. Stroke. 2018 Jan;49(1):175-183. doi: 10.1161/STROKEAHA.117.018593. PubMed PMID: 29273596; PubMed Central PMCID: PMC5744882.

Related compound libraries

This product is contained In the following compound libraries：

Antioxidant Compound Library Human Metabolite Library Bioactive Compounds Library Max Bioactive Compound Library Antidepressant Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dihydrolipoic acid 462-20-4 oxidation-reduction Antioxidant Reduced thioctic acid Lipopolysaccharide radical Reactive Oxygen Species centered anti-inflammatory oxygen Inhibitor inhibit Reduced lipoic acid DHLA Nrf2 ROS HO-1 USAF XR-12 ERK 6,8-Dihydrothioctic acid NLRP3 Depression Neuroinflammation inhibitor

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