Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 55.00 | |
25 mg | In stock | $ 73.00 | |
50 mg | In stock | $ 89.00 | |
100 mg | In stock | $ 139.00 | |
500 mg | In stock | $ 346.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling. |
Targets&IC50 | mTOR:48 μM |
In vitro | Intraperitoneal injection of 1 mg/kg Dihydromyricetin in rats neutralizes the symptoms of acute alcohol intoxication and eliminates signs of increased tolerance, heightened anxiety, and susceptibility to convulsions. The LD50 for intraperitoneal injection in mice is 1.41 g/kg. |
In vivo | Dihydromyricetin (1 μM), as an innovative anti-alcohol intoxication agent, antagonizes acute ethanol-induced enhancements in GABA(A)Rs, as well as increases in GABA(A)R plasticity and expression of the GABA(A)R α4 subunit in the hippocampus and cultured neurons due to ethanol exposure/withdrawal. Additionally, Dihydromyricetin effectively scavenges DPPH radicals and inhibits the increase in lipid peroxidation catalyzed by FeSO4 and ethylenediaminetetraacetic acid in the linoleic acid system. |
Source |
Synonyms | Ampelopsin, Ampeloptin |
Molecular Weight | 320.25 |
Formula | C15H12O8 |
CAS No. | 27200-12-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 60 mg/mL (187.4 mM)
DMSO: 60 mg/mL (187.4 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Dihydromyricetin 27200-12-0 Autophagy Cell Cycle/Checkpoint DNA Damage/DNA Repair Membrane transporter/Ion channel Microbiology/Virology Neuroscience PI3K/Akt/mTOR signaling DNA/RNA Synthesis GABA Receptor Influenza Virus mTOR inhibit Ampelopsin Mammalian target of Rapamycin Ampeloptin Inhibitor inhibitor