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Dihydrotanshinone I

Catalog No. T3374   CAS 87205-99-0
Synonyms: DHTS, 15,16-dihydrotanshinone I

Dihydrotanshinone I (DHTS) is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases.

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Dihydrotanshinone I Chemical Structure
Dihydrotanshinone I, CAS 87205-99-0
Pack Size Availability Price/USD Quantity
5 mg In stock $ 51.00
10 mg In stock $ 92.00
25 mg In stock $ 191.00
50 mg In stock $ 277.00
100 mg In stock $ 458.00
500 mg In stock $ 987.00
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Purity: 99.37%
Purity: 99%
Purity: 98.67%
Purity: 98%
Purity: 97.4%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dihydrotanshinone I (DHTS) is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases.
In vitro DHT (10 nM) decreases lectin-like ox-LDL receptor-1 (LOX-1) and NADPH oxidase 4 (NOX4) expression, reactive oxygen species (ROS) production, NF-κB nuclear translocation, ox-LDL endocytosis and monocytes adhesion in lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs)[1]. Dihydrotanshinone I induces caspase-dependent apoptosis induced in HCT116 cells. Dihydrotanshinone I induces concentration and ROS dependent caspase activation. Apoptosis induced by Dihydrotanshinone I is completely prevented by Z-VAD-fmk. Apoptosis induced by Dihydrotanshinone I is significantly inhibited by pretreatment of Z-LEHD-fmk but only is partially inhibited by Z-IETD-fmk. Apoptosis induced by Dihydrotanshinone I is significantly increased by caspase-2 knockdown[3].
In vivo In ApoE-/- mice fed with an atherogenic diet, DHT (10 and 25 mg kg-1) significantly attenuated atherosclerotic plaque formation, altered serum lipid profile, decreased oxidative stress and shrunk necrotic core areas. DHT dramatically inhibits the enhanced expression of LOX-1, NOX4, and NF-κB in aorta[1]. Dihydrotanshinone I (1, 2, 4 mg/kg) treatment can improve cardiac function, reduce infarct size, ameliorate the variations in myocardial zymogram and histopathological disorders, decrease 20-HETE generation, and regulate apoptosis-related protein in myocardial ischemia-reperfusion rats[2].
Kinase Assay Cells are treated with various concentrations of Dihydrotanshinone I (3.13-20 μM) for 48 h. For the activity assay, Ac-DEVD-AMC (1 μg/μL), Ac-IETD-AMC (1 μg/μL) or Ac-LEDH-AMC (1 μg/μL) and cell lysate are added into Protease Assay Buffer in 96-well plate. Reaction mixtures with lysis buffer are used as negative controls. Cells treated with DMSO (0.1%) are treated as vehicle control. The reaction mixtures are incubated for 1 h at 37°C. The AMC liberated from the substrates is measured using spectrofluorometer of Victor 2 plate reader with an excitation wavelength of 380 nm and an emission wavelength of 430 nm.
Source
Synonyms DHTS, 15,16-dihydrotanshinone I
Molecular Weight 278.3
Formula C18H14O3
CAS No. 87205-99-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.85 mg/mL (13.82 mM), Sonification is recommended

TargetMolReferences and Literature

1. Wei, Y., Xu, M., Ren, Y., Lu, G., Xu, Y., Song, Y., & Ji, H. (2016). The cardioprotection of dihydrotanshinone I against myocardial ischemia–reperfusion injury via inhibition of arachidonic acid ω-hydroxylase. Canadian Journal Of Physiology And Pharmacology, 94(12), 1267-1275. doi: 10.1139/cjpp-2016-0036 2. Wang L, et al. Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer. Phytomedicine. 2015 Nov 15;22(12):1079-87.

TargetMolCitations

1. Wei Z, Zhan X, Ding K, et al. Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo. Frontiers in Pharmacology. 2021: 2623. 2. Li X W, Yuan S C, Wang M, et al.Rosmarinic acid ameliorates autoimmune responses through suppression of intracellular nucleic acid-mediated type I interferon expression.Biochemical and Biophysical Research Communications.2023

Related compound libraries

This product is contained In the following compound libraries:
Ferroptosis Compound Library Anti-Fibrosis Compound Library Natural Product Library Anti-Viral Compound Library Nonsteroidal Anti-Inflammatory Compound Library Anti-Infection Compound Library Kinase Inhibitor Library Natural Product Library for HTS Traditional Mongolian Medicine Compound Library Terpene Natural Product Library

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Keywords

Dihydrotanshinone I 87205-99-0 Immunology/Inflammation Microbiology/Virology SARS-CoV ROS SARS coronavirus inhibit DHTS 15,16-dihydrotanshinone I Inhibitor inhibitor

 

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