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Diphylline

Catalog No. T0892   CAS 479-18-5
Synonyms: Dyphylline, Diprophylline

Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphylline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles. Diphylline may also antagonize adenosinereceptors. Diphylline is used in the treatment of acute bronchial asthma, chronic bronchitis and emphysema.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Diphylline Chemical Structure
Diphylline, CAS 479-18-5
Pack Size Availability Price/USD Quantity
50 mg In stock $ 44.00
100 mg In stock $ 62.00
500 mg In stock $ 179.00
1 mL * 10 mM (in DMSO) In stock $ 68.00
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Purity: 99.1%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphylline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles. Diphylline may also antagonize adenosinereceptors. Diphylline is used in the treatment of acute bronchial asthma, chronic bronchitis and emphysema.
Source
Synonyms Dyphylline, Diprophylline
Molecular Weight 254.24
Formula C10H14N4O4
CAS No. 479-18-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 48 mg/mL (188.8 mM)

H2O: 47 mg/mL (184.9 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Schwabe U, et al. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21.

TargetMolCitations

1. Zhang Z, Zhou H, Gu W, et al.CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes.Nature Chemical Biology.2024: 1-11.

Related compound libraries

This product is contained In the following compound libraries：
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Inhibitor Library Target-Focused Phenotypic Screening Library NO PAINS Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets
ONO-8430506 Pentoxifylline Nanterinone Tovinontrine N-Methylbenzamide Propentofylline Tofimilast Norbraylin

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Keywords

Diphylline 479-18-5 GPCR/G Protein Metabolism Neuroscience Adenosine Receptor PDE P1 receptor Dyphylline inhibit Diprophylline Phosphodiesterase (PDE) Inhibitor inhibitor

 

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