Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Domatinostat (4SC202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 45.00 | |
2 mg | In stock | $ 63.00 | |
5 mg | In stock | $ 101.00 | |
10 mg | In stock | $ 150.00 | |
25 mg | In stock | $ 287.00 | |
50 mg | In stock | $ 441.00 | |
100 mg | In stock | $ 649.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 118.00 |
Description | Domatinostat (4SC202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1. |
Targets&IC50 | HDAC1:1.20 μM, HDAC3:0.57 μM, HDAC2:1.12 μM |
In vitro | In HeLa cells, 4SC-202 induces hyperacetylation of histone H3 with EC50 of 1.1 μM. 4SC-202 induces a G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causing collapsed spindle apparatus and multiple nucleation centres. In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM. [1] |
In vivo | In vivo, 4SC-202 has a high oral bioavailability, and shows high metabolic stability and a low plasma clearance. 4SC-202 (120 mg/kg p.o.) shows pronounced and robust anti-tumor activity in both A549 NSCLC xenograft and RKO27 colon carcinoma model. [1] |
Synonyms | 4SC202, 4SC 202, 4SC-202 (free base), 4SC-202 |
Molecular Weight | 447.51 |
Formula | C23H21N5O3S |
CAS No. | 910462-43-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 82 mg/mL (183.2 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Domatinostat 910462-43-0 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair HDAC 4SC202 inhibit 4SC 202 4SC-202 (free base) 4SC-202 Inhibitor Histone deacetylases inhibitor