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Dot1L-IN-1

Catalog No. T11081   CAS 2088518-50-5

The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.

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Dot1L-IN-1 Chemical Structure
Dot1L-IN-1, CAS 2088518-50-5
Pack Size Availability Price/USD Quantity
25 mg 10-14 weeks $ 2,720.00
50 mg 10-14 weeks $ 3,580.00
100 mg 10-14 weeks $ 4,900.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
Targets&IC50 Dot1L(ki):ki:2 pM
In vitro Dot1l-in-1 significantly inhibited H3K79 dimethylation (IC50 = 3 nM) and HoxA9 promoter (IC50 = 17 nM) IN HeLa and MOLM-13 cells.Dot1l-in-1 effectively inhibited the proliferation of mL-recombinant human leukemia cell line MV4-11 carrying carcinogenic MLL-AF4 fusion (IC50 = 5 nM).
Molecular Weight 646.21
Formula C32H36ClN9O2S
CAS No. 2088518-50-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Möbitz H, et al. Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach. ACS Med Chem Lett. 2017 Feb 14;8(3):338-343.

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Keywords

Dot1L-IN-1 2088518-50-5 Chromatin/Epigenetic Histone Methyltransferase Dot1LIN1 Dot-1L-IN-1 Dot1L IN 1 inhibitor inhibit

 

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