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Duocarmycin SA

Catalog No. T11118   CAS 130288-24-3

Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA.Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro.

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Duocarmycin SA Chemical Structure
Duocarmycin SA, CAS 130288-24-3
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA.Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro.
Molecular Weight 477.47
Formula C25H23N3O7
CAS No. 130288-24-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. 2. Boyle KE, et al. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2688-2692.

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Keywords

Duocarmycin SA 130288-24-3 Others inhibitor inhibit

 

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