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Dynorphin A 1-10 acetate(79994-24-4 free base)

Catalog No. TP1813L CAS TP1813L

Dynorphin A (1-10) acetate is an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.

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Dynorphin A 1-10 acetate(79994-24-4 free base) Chemical Structure

Dynorphin A 1-10 acetate(79994-24-4 free base), CAS TP1813L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 101.00
5 mg	In stock	$ 339.00
10 mg	In stock	$ 515.00
25 mg	In stock	$ 837.00
50 mg	In stock	$ 1,160.00
100 mg	In stock	$ 1,560.00
500 mg	In stock	$ 3,120.00

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Purity: 99.88%

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Description

In vitro

Dynorphin A (1-10) binds in the transmembrane domain of the κ-receptor[1]. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC50 is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks INMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors[2].

Molecular Weight	1294.53
Formula	C59H95N19O14
CAS No.	TP1813L

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keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Paterlini G, et al. Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the kappa-opioidreceptor. A model for receptor activation. J Med Chem. 1997 Sep 26;40(20):3254-62.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Neurotransmitter Receptor Compound Library

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Keywords

Dynorphin A 1-10 acetate(79994-24-4 free base) TP1813L Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Dynorphin A 1 10 acetate(79994 24 4 free base) Dynorphin A 110 acetate(79994244 free base) inhibitor inhibit

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