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EGFR-IN-5

Catalog No. T11160   CAS 2225887-26-1

EGFR-IN-5 is a selective inhibitor of EGFR. The IC50s for EGFR, EGFR(L858R), EGFR(L858R/T790M), and EGFR(L858R/T790M/C797S) are 10.4, 1.1, 34, 7.2 nM, respectively.

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EGFR-IN-5 Chemical Structure
EGFR-IN-5, CAS 2225887-26-1
Pack Size Availability Price/USD Quantity
5 mg In stock $ 266.00
50 mg In stock $ 1,450.00
100 mg In stock $ 2,530.00
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Purity: 98.17%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description EGFR-IN-5 is a selective inhibitor of EGFR. The IC50s for EGFR, EGFR(L858R), EGFR(L858R/T790M), and EGFR(L858R/T790M/C797S) are 10.4, 1.1, 34, 7.2 nM, respectively.
Targets&IC50 EGFR:10.4 nM, EGFRL858R/T790M:34 nM, EGFRL858R/T790M/C797S:7.2 nM, EGFRL858R:1.1 nM
Molecular Weight 571.69
Formula C31H38FN9O
CAS No. 2225887-26-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (209.90 mM), sonification is recommended.

TargetMolReferences and Literature

1. Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library

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Keywords

EGFR-IN-5 2225887-26-1 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR inhibit Epidermal growth factor receptor HER1 ErbB-1 Inhibitor EGFR IN 5 EGFRIN5 inhibitor

 

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