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ER-000444793

Catalog No. T15241 CAS 792957-74-5

ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).

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ER-000444793, CAS 792957-74-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 70.00
5 mg	In stock	$ 163.00
10 mg	In stock	$ 247.00
25 mg	In stock	$ 490.00
50 mg	In stock	$ 715.00
100 mg	In stock	$ 987.00
500 mg	In stock	$ 1,980.00
1 mL * 10 mM (in DMSO)	In stock	$ 178.00

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Purity: 99.55%

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Description	ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).
Targets&IC50	mPTP:2.8 μM
In vitro	ER-000444793 is a small molecule and non-toxic mPTP inhibitor. It also has a mechanism of action independent of CypD inhibition. Both CsA and SfA dose-dependently reduce HTRF signal, showing the displacement of labeled CsA from rhCypD protein (CsA IC50=23?nM and SfA IC50=?5?nM). However, ER-000444793 has no effect up to a concentration of 50?μM, showing be short of displacement of labelled-CsA from rhCypD protein. ER-000444793 potently and dose-dependently inhibits Ca2+-induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. These data display the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition[1].

Molecular Weight	354.4
Formula	C23H18N2O2
CAS No.	792957-74-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (141.08 mM), Sonication is recommended.

References and Literature

1. Briston T, et al. Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria. Sci Rep. 2016 Nov 25;6:37798.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Metabolism Compound Library Mitochondria-Targeted Compound Library Anti-Aging Compound Library Reprogramming Compound Library NO PAINS Compound Library Cuproptosis Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

ER-000444793 792957-74-5 Metabolism Others Mitochondrial Metabolism Inhibitor inhibit ER000444793 ER 000444793 inhibitor

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