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EST64454 hydrochloride

Catalog No. T8834 CAS 1950569-11-5

Synonyms: EST64454

EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.

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EST64454 hydrochloride Chemical Structure

EST64454 hydrochloride, CAS 1950569-11-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 135.00
2 mg	In stock	$ 193.00
5 mg	In stock	$ 283.00
10 mg	In stock	$ 452.00
25 mg	In stock	$ 745.00
50 mg	In stock	$ 1,050.00
100 mg	In stock	$ 1,390.00
1 mL * 10 mM (in DMSO)	In stock	$ 333.00

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Purity: 99.15%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.
Targets&IC50	σ1:22 nM(Ki)

Synonyms	EST64454
Molecular Weight	400.85
Formula	C18H23ClF2N4O2
CAS No.	1950569-11-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (49.89 mM)

References and Literature

1. José Luis Díaz, Mónica García, Torrens A , et al. EST64454: a Highly Soluble σ 1 Receptor Antagonist Clinical Candidate for Pain Management[J]. Journal of Medicinal Chemistry, 2020, 63(23):14979-14988.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Bioactive Compound Library Orally Active Compound Library Neuronal Signaling Compound Library

Related Products

Related compounds with same targets

Blarcamesine hydrochloride σ1 Receptor antagonist-1 KSK67 KB-5492 FA BD 1008 dihydrobromide NE-100 hydrochloride Glycerol phenylbutyrate-D5 AB21 HCl

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

EST64454 hydrochloride 1950569-11-5 GPCR/G Protein Sigma receptor pain EST-64454 Hydrochloride EST 64454 Hydrochloride EST-64454 Inhibitor nerve EST 64454 EST64454 selective EST-64454 hydrochloride Sigma Receptor oral EST64454 Hydrochloride inhibit inhibitor

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