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Neuroscience ATP Citrate Lyase ETC-1002

ETC-1002

Catalog No. T3625   CAS 738606-46-7
Synonyms: ETC1002, ETC 1002, Bempedoic acid, ESP-55016
Purity 99.94% Datasheet

ETC-1002, also known as ESP-55016 and Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic acid is absorbed rapidly in the small intestine and enters the liver through cell surface receptors different from those transporters that selectively take up statins. Bempedoic acid is a regulator of lipid and carbohydrate metabolism.

ETC-1002, CAS 738606-46-7
Pack Size Availability Price/USD Quantity
2 mg In stock 29.00
5 mg In stock 50.00
10 mg In stock 75.00
25 mg In stock 142.00
50 mg In stock 255.00
100 mg In stock 410.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ETC-1002, also known as ESP-55016 and Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic acid is absorbed rapidly in the small intestine and enters the liver through cell surface receptors different from those transporters that selectively take up statins. Bempedoic acid is a regulator of lipid and carbohydrate metabolism.
Targets&IC50 ACL :ic50 29μM,  
Kinase Assay 7.5× compounds are added to a 96-well PolyPlate containing 60 μL of Buffer per well with substrates CoA (200 μM), ATP (400 μM), and [14C]citrate. Reaction is started with 4 μL (300 ng/well) ACL, and the plate is incubated at 37°C for 3 h. Th
Cell Research
Primary rat hepatocytes and differentiated human MDMs are treated with indicated concentrations of ETC-1002 for 12 h. Working solutions of ETC-1002 are prepared in serum-free RPMI 1640 containing 12 mM HEPES, 10,000 U/ml penicillin, and 100 μg/ml streptomycin. (Only for Reference)
Cell lines: Primary rat hepatocytes and differentiated human monocyte-derived macrophages
Animal Research
Animal Model: C57BL/6 mice
Synonyms ETC1002, ETC 1002, Bempedoic acid, ESP-55016
Purity 99.90%
Appearance solid
Molecular Weight 344.49
Formula C19H36O5
CAS No. 738606-46-7

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 63 mg/mL (182.9 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Nikolic D, et al. Atherosclerosis. 2014, 237(2):705-710. 2. Filippov S, et al. J Lipid Res. 2013, 54(8):2095-2108. 3. Pinkosky SL, et al. J Lipid Res. 2013, 54(1):134-151.

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Neuronal Signaling Compound Library Epigenetics Compound Library PI3K-AKT-mTOR Compound Library Kinase Inhibitor Library Anti-Metabolism Disease Compound Library Anti-cancer Metabolism Compound Library

Related Products

Related compounds with same targets
Acetylcysteine NDI-091143 Hydroxycitric acid tripotassium hydrate SB 204990 ETC-1002

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