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ETHYL CAFFEATE

Catalog No. T5681   CAS 102-37-4
Synonyms: ETHYL 3,4-DIHYDROXYCINNAMATE

Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related signaling, including IFN-γ, T-bet, STAT1, and STAT4.

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ETHYL CAFFEATE Chemical Structure
ETHYL CAFFEATE, CAS 102-37-4
Pack Size Availability Price/USD Quantity
10 mg In stock $ 41.00
25 mg In stock $ 74.00
50 mg In stock $ 124.00
100 mg In stock $ 198.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related signaling, including IFN-γ, T-bet, STAT1, and STAT4.
In vitro In vivo, ETHYL CAFFEATE(ECF) treatment reduced the severity of collagen-induced arthritis (CIA), inhibited IFN-γ and IL-6 secretion, and?decreased the proportion of CD11b+Gr-1+ splenic neutrophil.?Meanwhile, ECF treatment significantly inhibited the IFN-γ expression in CD4+T cell without obviously influencing the development of Th17 cells and T regulatory cells.
In vivo Shikui X , Aixue Z , Zengjun G , et al. Ethyl Caffeate Ameliorates Collagen-Induced Arthritis by Suppressing Th1 Immune Response[J]. Journal of Immunology Research, 2017, 2017:1-11.
Kinase Assay The proliferation of splenocytes or T cells in response to ConA, LPS, and anti-CD3/28 was measured by CCK-8 Kit.?Briefly, BALB/c splenocyte suspension (5?×?105 cells/well) was cultured with ConA (5?μg/ml), LPS (10?μg/ml), and anti-CD3 (5?μg/ml;?145-2C11) in the presence of ECF at indicated concentrations.?The cultures were incubated for 48?h, 20?μl of CCK-8 was then added to each well before the end of culture, and OD value was read at 450?nm.?The MTT method was used to measure the cytotoxicity of the sample.?Splenocytes (5?×?105 cells/well) were cultured in triplicates in the absence or presence of ECF in a 96-well flat-bottomed plate (Costar) for 48?h.?MTT (5?mg/ml) was pulsed for 4?h prior to the end of the culture.?Upon removal of MTT/medium, 150?μl of DMSO was added to each well, and the plate was agitated on an oscillator for 5?min to dissolve the precipitate.?The assay plate was read at 570?nm using a microplate reader.
Cell Research Collagen was dissolved in 0.1 M acetic acid at 4°C overnight.?Male DBA/1 mice were immunized at the tail base with 125?μg of collagen emulsified in complete Freund's adjuvant (CFA) containing Mycobacterium tuberculosis strain H37Rv.?Each mouse was then boosted with the same amount of collagen plus CFA 21 days later (taken as day 0). Starting from day 9 for 10 consecutive days, the mice were administered daily with ECF (50?mg/kg) or methotrexate (2?mg/kg)
Synonyms ETHYL 3,4-DIHYDROXYCINNAMATE
Molecular Weight 208.21
Formula C11H12O4
CAS No. 102-37-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 41 mg/mL (196.91 mM)

TargetMolReferences and Literature

1. Shikui X , Aixue Z , Zengjun G , et al. Ethyl Caffeate Ameliorates Collagen-Induced Arthritis by Suppressing Th1 Immune Response[J]. Journal of Immunology Research, 2017, 2017:1-11.

TargetMolCitations

1. Chen Z, Yuan Y, Yang D, et al. Antiviral activities of Polygonum Perfoliatum L. extract and related phenolic acid constituents against hepatitis B virus. Journal of Medical Virology. 2022

Related compound libraries

This product is contained In the following compound libraries:
Miao medicine Compound Library Pyroptosis Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Selected Plant-Sourced Compound Library Bioactive Compounds Library Max RO5 Drug-like Natural Product Library Traditional Chinese Medicine Monomer Library Tibetan medicine Compound Library Antidepressant Compound Library Bioactive Compound Library

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Keywords

ETHYL CAFFEATE 102-37-4 Immunology/Inflammation Neuroscience NF-Κb NF-κB COX PGE Synthase NO Synthase Nuclear factor-kappaB Inhibitor Cyclooxygenase PGE synthase Prostaglandin E synthase inhibit Nitric oxide synthases NOS ETHYL 3,4-DIHYDROXYCINNAMATE Nuclear factor-κB inhibitor

 

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