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Edaravone

Catalog No. T0407 CAS 89-25-8

Synonyms: MCI-186

Edaravone (MCI-186)(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.

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Edaravone, CAS 89-25-8

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500 mg	In stock	$ 43.00
5 g	In stock	$ 52.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 100%

Purity: 99.44%

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Description	Edaravone (MCI-186)(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.
In vitro	Edaravone significantly improves neurological function in animals. Treatment with edaravone substantially reduces TUNEL-positive apoptotic cells and increases the expression of Bcl-2, while decreasing the immunoreactivity of Bax protein in the peri-infarct area. The research demonstrates that edaravone provides excellent protection against ischemic/reperfusion-induced brain injury through a Bcl-2/Bax protein-dependent anti-apoptotic mechanism. Following a 24-hour infusion of edaravone into murine brain tissue, there is a notable reduction in infarct volume and amelioration of neurological deficits. In the early stages post-reperfusion, edaravone significantly inhibits the accumulation of HNE-modified proteins and 8-OHdG in the penumbral region, reduces the expression of iNOS, diminishes microglial activation, and lowers the formation of nitrotyrosine. Edaravone also markedly attenuates renal function and pathological outcomes in rat kidneys, significantly reducing free radical production in renal tubular epithelial cells as indicated by fluorescence.
In vivo	Edaravone optimizes the state of NOS by reducing the detrimental isoforms iNOS and nNOS, while increasing the beneficial eNOS, thus favoring neuroprotection in ischemic stroke. It inhibits oxidation and enhances eNOS expression without boosting production, improving and preserving cerebral blood flow during reperfusion without necessitating peroxynitrite formation. Edaravone exerts its neuroprotective effect by mitigating neuronal damage from cerebral ischemia and inhibiting endothelial injury.
Cell Research	Cell viability is quantified by MTT assay and trypan blue staining. MTT (5?mg/mL, 20?μL) is added to each well and incubated for 4?h at 37°C after the drug treatments. The medium is removed and the cell pellet is dissolved in DMSO. Then, the optical density (OD) values are measured at 570?nm using an ELISA reader.

Synonyms	MCI-186
Molecular Weight	174.2
Formula	C10H10N2O
CAS No.	89-25-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 17.4 mg/mL (100 mM)

References and Literature

1. Yoshida H, et al. CNS Drug Rev, 2006, 12(1), 9-20. 2. Zhang N, et al. Stroke, 2005, 36(10), 2220-2225. 3. Doi K, et al. Kidney Int, 2004, 65(5), 1714-1723. 4. Amemiya S, et al. Eur J Pharmacol, 2005, 516(2), 125-130. 6. Bai X, et al. Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plast. 2016;2016:4034218. Epub 2016 Nov 10. 7. Wang F, Li R, Tu P, et al. Total glycosides of Cistanche deserticola promote neurological function recovery by inducing neurovascular regeneration via Nrf-2/Keap-1 pathway in MCAO/R rats[J]. Frontiers in Pharmacology. 2020, 11.

Citations

1. Wang F, Li R, Tu P, et al. Total glycosides of Cistanche deserticola promote neurological function recovery by inducing neurovascular regeneration via Nrf-2/Keap-1 pathway in MCAO/R rats. Frontiers in Pharmacology. 2020, 11.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library High Solubility 3D Diversity Fragment Library Clinical Compound Library FDA-Approved Drug Library Anti-Cancer Compound Library Apoptosis Compound Library

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Keywords

Edaravone 89-25-8 Apoptosis oxidation-reduction Proteases/Proteasome Free radical scavengers MMP Inhibitor Matrix metalloproteinases MCI 186 MCI-186 inhibit MCI186 inhibitor

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