Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
2 mg | In stock | $ 71.00 | |
5 mg | In stock | $ 135.00 | |
10 mg | In stock | $ 205.00 | |
25 mg | In stock | $ 413.00 | |
50 mg | In stock | $ 613.00 | |
100 mg | In stock | $ 873.00 | |
500 mg | In stock | $ 1,780.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 146.00 |
Description | Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity. |
Targets&IC50 | ATR:7 nM |
In vitro | Elimusertib hydrochloride potently inhibits the proliferation of a broad spectrum of human tumor cell lines (median IC50: 78 nM). BAY-1895344 potently suppresses NSC-32065-induced H2AX phosphorylation (IC50: 36 nM) [1]. |
In vivo | In a variety of xenograft models of ovarian and colorectal cancer, Elimusertib hydrochloride shows potent anti-tumor efficacy in monotherapy and causes complete tumor remission in mantle cell lymphoma models [2]. |
Synonyms | BAY-1895344 hydrochloride |
Molecular Weight | 411.89 |
Formula | C20H22ClN7O |
CAS No. | T10468 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (121.39 mM), Sonication and heating are recommended.
H2O: 48 mg/mL (116.53 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Elimusertib hydrochloride(1876467-74-1 free base) T10468 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR BAY1895344 Hydrochloride BAY 1895344 Hydrochloride BAY-1895344 hydrochloride Elimusertib hydrochloride(1876467 74 1 free base) Elimusertib hydrochloride(1876467741 free base) BAY-1895344 Hydrochloride inhibitor inhibit