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Eltoprazine hydrochloride

Catalog No. T7498 CAS 98206-09-8

Synonyms: DU 28853 hydrochloride

Eltoprazine hydrochloride (DU 28853 hydrochloride) is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively).

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Eltoprazine hydrochloride Chemical Structure

Eltoprazine hydrochloride, CAS 98206-09-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 32.00
5 mg	In stock	$ 51.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 328.00
100 mg	In stock	$ 487.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 99.94%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Eltoprazine hydrochloride (DU 28853 hydrochloride) is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively).
Targets&IC50	5-HT1A:40 nM , 5-HT2B:81 nM, 5-HT1B:52 nM
In vivo	Eltoprazine hydrochloride exerts a dose-dependent decrease in aggressive behavior in resident-intruder tests with rats (ID50 = 0.24 mg/kg)[1].

Synonyms	DU 28853 hydrochloride
Molecular Weight	256.73
Formula	C12H17ClN2O2
CAS No.	98206-09-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31 mg/mL (120.75 mM)

H2O: 28 mg/mL (109.06 mM)

References and Literature

1. Boer S F D , Lesourd M , Mocaer E , et al. Selective Antiaggressive Effects of Alnespirone in Resident-Intruder Test Are Mediated via 5-Hydroxytryptamine1A Receptors: A Comparative Pharmacological Study with 8-Hydroxy-2-Dipropylaminotetralin, Ipsapirone, Buspirone, Eltoprazine, and WAY-100635[J]. Journal of Pharmacology & Experimental Therapeutics, 1999, 288(3):1125-1133. 2. Gravius A , Dekundy A , Vanaga A , et al. Further pharmacological characterization of eltoprazine: Focus on its anxiolytic, anorexic, and adverse-effect potential[J]. Acta neurobiologiae experimentalis, 2017, 77(1):77-85.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Drug Library Serotonin Receptor-Targeted Compound Library Anti-Cancer Compound Library Angiogenesis related Compound Library Anti-Parkinson's Disease Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Eltoprazine hydrochloride 98206-09-8 GPCR/G Protein Neuroscience 5-HT Receptor DU-28853 DU 28853 Hydrochloride 5-hydroxytryptamine Receptor Inhibitor DU-28853 Hydrochloride DU 28853 DU28853 inhibit Eltoprazine Hydrochloride DU28853 Hydrochloride Serotonin Receptor DU 28853 hydrochloride Eltoprazine inhibitor

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