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Enocitabine

Catalog No. T15235   CAS 55726-47-1

Enocitabine is a nucleoside analog. Enocitabine inhibits the replication of human cytomegalovirus(HCMV) and it also has antileukemic and antiviral activities. Enocitabine is also a potent DNA replication inhibitor and a DNA chain terminator.

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Enocitabine Chemical Structure
Enocitabine, CAS 55726-47-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 155.00
5 mg In stock $ 328.00
10 mg In stock $ 563.00
25 mg In stock $ 889.00
50 mg In stock $ 1,180.00
100 mg In stock $ 1,590.00
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Purity: 98.02%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Enocitabine is a nucleoside analog. Enocitabine inhibits the replication of human cytomegalovirus(HCMV) and it also has antileukemic and antiviral activities. Enocitabine is also a potent DNA replication inhibitor and a DNA chain terminator.
In vitro The combined effects of Pirarubicin and Enocitabine on HeLa S3 human uterine cervix carcinoma and K562 human myelocytic leukemia cells are determined by enhancement of their cytotoxic activities. Enocitabine or etoposide shows synergistic effects on HeLa S3 and K562 cells [2]. In the presence of Enocitabine, triphosphate forms of the nucleoside analogs are detected in the human cytomegalovirus (HCMV)-infected cells, and synthesis of HCMV DNA is strongly suppressed [3].
Molecular Weight 565.78
Formula C31H55N3O6
CAS No. 55726-47-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2 mg/mL (3.53 mM), Need ultrasonic and warming and heat to 60°C

TargetMolReferences and Literature

1. Hamada A, et al. Clinical pharmacokinetics of cytarabine formulations.Clin Pharmacokinet. 2002;41(10):705-18. 2. Nagasawa M, et al.In vitro combined effects of pirarubicin (THP) and various antitumor drugs on human tumor cell lines. Gan To Kagaku Ryoho. 1990 Apr;17(4 Pt 1):633-8. 3. Nakamura K, et al. Antiviral effect of antileukemic drugs N4-behenoyl-1-beta-D-arabinofuranosylcytosine (BH-AC) and 2,2'-anhydro-1-beta-D-arabinofuranosylcytosine (cyclo-C) against human cytomegalovirus. J Med Virol. 1990 Jun;31(2):141-7.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Approved Drug Library Anti-Cancer Compound Library Nucleotide Compound Library Inhibitor Library FDA-Approved & Pharmacopeia Drug Library Drug Repurposing Compound Library Anti-Viral Compound Library

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Keywords

Enocitabine 55726-47-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Proteases/Proteasome HCV Protease Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Inhibitor CMV inhibit Sunrabin Cytomegalovirus AML acute myelogenous leukaemia inhibitor

 

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