Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 148.00 | |
5 mg | In stock | $ 369.00 | |
10 mg | In stock | $ 552.00 | |
25 mg | In stock | $ 890.00 | |
50 mg | In stock | $ 1,220.00 | |
100 mg | In stock | $ 1,630.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 360.00 |
Description | Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion. |
In vitro |
A herbal compound fargesin obtained from M. fargesii, has exerted anti-inflammatory effects in human monocytic THP-1 cells in the previous study.?it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells.?Furthermore, it was investigated the modulating effects of epimagnolin A on mitogen-activated protein kinase, nuclear factor-kappa B (NF-κB), and activator protein 1 (AP-1) activities.?Phosphorylation of p38 and nuclear translocation of p50 and c-Jun were down-regulated by epimagnolin A in the PMA-stimulated THP-1 cell.?The results revealed that epimagnolin A attenuated the binding affinity of NF-κB and AP-1 transcription factors to IL-6 promoter and IL-6 production through p38/NF-kB and AP-1 signaling pathways in the PMA-stimulated THP-1 cells.?These results suggest that epimagnolin A can be a useful drug for the treatment of inflammatory diseases[2]. |
Source |
Molecular Weight | 416.46 |
Formula | C23H28O7 |
CAS No. | 41689-51-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/mL (28.81 mM)
You can also refer to dose conversion for different animals. More
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Epimagnolin A 41689-51-4 Microbiology/Virology Parasite furfuran inhibit Inhibitor lignan antiplasmodial inhibitor