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Epimagnolin B

Catalog No. TN1009 CAS 1134188-26-3

Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear translocation of p65 subunit of NF-kappaB. It also exhibits antiallergic effects without affecting the viability of bone marrow-derived mast cells.

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Epimagnolin B, CAS 1134188-26-3

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Purity: 98%

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Description	Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear translocation of p65 subunit of NF-kappaB. It also exhibits antiallergic effects without affecting the viability of bone marrow-derived mast cells.
In vitro	The overproduction of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) causes neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)-yangambin (3) and a new structure named as Epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia[1]

Molecular Weight	416.46
Formula	C23H28O7
CAS No.	1134188-26-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii.Bioorg Med Chem Lett. 2009 Feb 1;19(3):937-40.

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Keywords

Epimagnolin B 1134188-26-3 G蛋白偶联受体 NF-Kb信号通路免疫与炎症 NF-κB NO Synthase Prostaglandin Receptor Inhibitor inhibit inhibitor

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