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Erucic acid

Catalog No. T4867   CAS 112-86-7
Synonyms: Prifac 2990, 13(Z)-Docosenoic Acid, cis-13-docosenoic acid

Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Erucic acid (13(Z)-Docosenoic Acid) is broken down long-chain acyl-coenzyme A (CoA) dehydrogenase, which is produced in the liver. This enzyme breaks this long chain fatty acid into shorter-chain fatty acids. human infants have relatively low amounts of this enzyme and because of this, babies should not be given foods high in erucic acid. Erucic acid is found to be associated with isovaleric acidemia, which is an inborn error of metabolism.

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Erucic acid Chemical Structure
Erucic acid, CAS 112-86-7
Pack Size Availability Price/USD Quantity
100 mg In stock $ 45.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 97.85%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Erucic acid (13(Z)-Docosenoic Acid) is broken down long-chain acyl-coenzyme A (CoA) dehydrogenase, which is produced in the liver. This enzyme breaks this long chain fatty acid into shorter-chain fatty acids. human infants have relatively low amounts of this enzyme and because of this, babies should not be given foods high in erucic acid. Erucic acid is found to be associated with isovaleric acidemia, which is an inborn error of metabolism.
Synonyms Prifac 2990, 13(Z)-Docosenoic Acid, cis-13-docosenoic acid
Molecular Weight 338.57
Formula C22H42O2
CAS No. 112-86-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 197.9 mM

TargetMolReferences and Literature

1. Aubourg P , Adamsbaum C , Lavallardrousseau M C , et al. A two-year trial of oleic and erucic acids ("Lorenzo's oil") as treatment for adrenomyeloneuropathy.[J]. New England Journal of Medicine, 1993, 329(11):745. 2. Brown D G , Rao S , Weir T L , et al. Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool[J]. Cancer & Metabolism, 2016, 4(1):11. 3. Dercksen M , Kulik W , Mienie L J , et al. Polyunsaturated fatty acid status in treated isovaleric acidemia patients[J]. European Journal of Clinical Nutrition, 2016, 70(10). 4. Bu B , Ashwood P , Harvey D , et al. Fatty acid compositions of red blood cell phospholipids in children with autism[J]. Prostagrandins Leukot Essent Fatty Acids, 2006, 74(4):215-221. 5. Rizzo W B , Leshner R T , Odone A , et al. Dietary erucic acid therapy for X‐linked adrenoleukodystrophy[J]. Neurology, 1989, 39(11):1415-1422. 6. Kim E, et al. The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice. Pharmacol Biochem Behav. 2016 Mar;142:85-90.

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This product is contained In the following compound libraries:
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Keywords

Erucic acid 112-86-7 Metabolism PI3K/Akt/mTOR signaling PI3K Endogenous Metabolite Prifac 2990 inhibit 13(Z)-Docosenoic Acid Phosphoinositide 3-kinase 13Docosenoic Acid cis-13-docosenoic acid Inhibitor inhibitor

 

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