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Escitalopram Oxalate

Catalog No. T6493   CAS 219861-08-2
Synonyms: Cipralex, (S)-(+)Citalopram oxalate

Escitalopram Oxalate ((S)-(+)Citalopram oxalate) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.

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Escitalopram Oxalate Chemical Structure
Escitalopram Oxalate, CAS 219861-08-2
Pack Size Availability Price/USD Quantity
10 mg In stock $ 33.00
25 mg In stock $ 50.00
50 mg In stock $ 61.00
100 mg In stock $ 83.00
200 mg In stock $ 127.00
500 mg In stock $ 208.00
1 g In stock $ 297.00
1 mL * 10 mM (in DMSO) In stock $ 37.00
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Purity: 99.9%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Escitalopram Oxalate ((S)-(+)Citalopram oxalate) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
Targets&IC50 5-HT:0.89 nM(Ki)
In vitro Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase.
Synonyms Cipralex, (S)-(+)Citalopram oxalate
Molecular Weight 414.43
Formula C22H23FN2O5
CAS No. 219861-08-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 20.7 mg/mL (50 mM)

DMSO: 41.4 mg/mL (100 mM)

TargetMolReferences and Literature

1. Mnie-Filali O, et al. Encephale, 2007, 33(6), 965-972. 2. Zhang P, et al. J Med Chem, 2010, 53(16), 6112-6121.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Fluorochemical Library Bioactive Compound Library FDA-Approved Drug Library Antidepressant Compound Library Immunology/Inflammation Compound Library FDA-Approved & Pharmacopeia Drug Library

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Related compounds with same targets
Dasotraline hydrochloride Cinchonidine Citalopram hydrobromide Fluoxetine Azaphen Deschloroclozapine Nitroxazepine DOV-216,303 Free Base

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Keywords

Escitalopram Oxalate 219861-08-2 GPCR/G Protein Neuroscience Others Serotonin Transporter 5-HT Receptor reuptake Citalopram Oxalate impairments selectivity antidepressant inhibit SLC6A4 Inhibitor Cipralex cognitive 5-HTT SERT depression Escitalopram S-enantiomer (S)-Citalopram (S)-(+)Citalopram oxalate inhibitor

 

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