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Esomeprazole Magnesium

Catalog No. T2686   CAS 161973-10-0
Synonyms: (S)-Omeprazole magnesium, NEXIUM, (-)-Omeprazole magnesium

Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases

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Esomeprazole Magnesium Chemical Structure
Esomeprazole Magnesium, CAS 161973-10-0
Pack Size Availability Price/USD Quantity
25 mg In stock $ 35.00
50 mg In stock $ 45.00
100 mg In stock $ 62.00
200 mg In stock $ 90.00
1 mL * 10 mM (in DMSO) In stock $ 47.00
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Purity: 98.84%
Purity: 98.76%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases
Kinase Assay Purified enzyme assays: ATM for use in the in vitro assay is obtained from HeLa nuclear extract by immunoprecipitation with rabbit polyclonal antiserum raised to the COOH-terminal 400 amino acids of ATM in buffer containing 25 mM HEPES (pH 7.4), 2 mM MgCl2, 250 mM KCl, 500 μM EDTA, 100 μM Na3VO4, 10% v/v glycerol, and 0.1% v/v Igepal. ATM-antibody complexes are isolated from nuclear extract by incubating with protein A-Sepharose beads for 1 hour and then through centrifugation to recover the beads. In the well of a 96-well plate, ATM-containing Sepharose beads are incubated with 1 μg of substrate glutathione S-transferase–p53N66 (NH2-terminal 66 amino acids of p53 fused to glutathione S-transferase) in ATM assay buffer [25 mM HEPES (pH 7.4), 75 mM NaCl, 3 mM MgCl2, 2 mM MnCl2, 50 μM Na3VO4, 500 μM DTT, and 5% v/v glycerol] at 37 °C in the presence or absence of inhibitor. After 10 minutes with gentle shaking, ATP is added to a final concentration of 50 μM and the reaction continued at 37 °C for an additional 1 hour. The plate is centrifuged at 250 × g for 10 minutes (4 °C) to remove the ATM-containing beads, and the supernatant is removed and transferred to a white opaque 96-well plate and incubated at room temperature for 1.5 hours to allow glutathione S-transferase-p53N66 binding. This plate is then washed with PBS, blotted dry, and analyzed by a standard ELISA technique with a phospho-serine 15 p53 antibody. The detection of phosphorylated glutathione S-transferase-p53N66 substrate is performed in combination with a goat antimouse horseradish peroxidase-conjugated secondary antibody. Enhanced chemiluminescence solution is used to produce a signal and chemiluminescent detection is carried out.
Synonyms (S)-Omeprazole magnesium, NEXIUM, (-)-Omeprazole magnesium
Molecular Weight 713.12
Formula C34H36MgN6O6S2
CAS No. 161973-10-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 143 mg/mL (200.52 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 143 mg/mL (200.52 mM)

TargetMolReferences and Literature

1. Kumar P, et al. Drug Deliv Transl Res. 2015 Jun;5(3):243-56.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Aging Compound Library Orally Active Compound Library FDA-Approved & Pharmacopeia Drug Library Pediatric Drug Library Clinical Compound Library Drug Repurposing Compound Library Anti-Infection Compound Library

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Keywords

Esomeprazole Magnesium 161973-10-0 Membrane transporter/Ion channel ATPase Proton pump (S)-Omeprazole antioxidant inhibit K+-ATPase Esomeprazole Cu/Zn-superoxide disorders Omeprazole magnesium intestinal (S)-Omeprazole magnesium Proton Pump NEXIUM (-)-Omeprazole magnesium Inhibitor inhibitor

 

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