Powder: -20°C for 3 years | In solvent: -80°C for 1 year
.Estradiol 3-sulfamate inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. Estradiol 3-sulfamate is a potent, long-acting, and orally active steroid sulfatase inhibitor.
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 290.00 |
Description | .Estradiol 3-sulfamate inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. Estradiol 3-sulfamate is a potent, long-acting, and orally active steroid sulfatase inhibitor. |
Targets&IC50 | estrone sulfatase:251 nM |
In vitro | Introduction of a fluoro, chloro, or bromo moiety at the C-2 position of EMATE and Estradiol 3-sulfamate and that of a fluoro moiety at the C-4 position of the parent sulfamates markedly increase the estrone sulfatase inhibitory activity. |
In vivo | Estradiol 3-sulfamate is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, and both compounds have already been shown to be potent, long-acting, and orally active STS inhibitors. |
Synonyms | ES-J 995, E2MATE, BLE 00084 |
Molecular Weight | 351.46 |
Formula | C18H25NO4S |
CAS No. | 172377-52-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (177.83 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Estradiol 3-sulfamate 172377-52-5 Others BLE-00084 Estradiol 3 sulfamate ES-J 995 BLE00084 E2MATE Estradiol 3sulfamate ES-J-995 ES-J995 BLE 00084 inhibitor inhibit