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Ethambutol dihydrochloride

Catalog No. T0810 CAS 1070-11-7

Synonyms: Ethambutol 2HCl, Emb dihydrochloride, CL40881

Ethambutol dihydrochloride (CL40881) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.

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Ethambutol dihydrochloride Chemical Structure

Ethambutol dihydrochloride, CAS 1070-11-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ethambutol dihydrochloride (CL40881) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.
In vitro	In animal models, Ethambutol is administered orally at a dosage of 100 mg/kg.
In vivo	Ethambutol primarily targets the product of the embB gene, inducing mutations within the emb gene in drug-resistant strains of tuberculosis. In Mycobacterium smegmatis, Ethambutol affects arabinogalactan and lipoarabinomannan biosynthesis.

Synonyms	Ethambutol 2HCl, Emb dihydrochloride, CL40881
Molecular Weight	277.24
Formula	C10H26Cl2N2O2
CAS No.	1070-11-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 52 mg/mL (187.6 mM)

H2O: 51 mg/mL (184 mM)

References and Literature

1. No authors listed. Tuberculosis (Edinb), 2008, 88(2), 102-105. 2. Rastogi N, et al. Curr Microbiol. 1996, 33(3), 167-175. 3. Kaur D, et al. Int J Antimicrob Agents, 2001, 17(1), 51-55.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Microbial Natural Product Library Clinical Compound Library Anti-infective Natural Product Library Orally Active Compound Library Anti-COVID-19 Compound Library Anti-Fungal Compound Library Immunology/Inflammation Compound Library RO5 Drug-like Natural Product Library Approved Drug Library

Related Products

Related compounds with same targets

Cefathiamidine Diaveridine Bavachalcone Dihydrostreptomycin sulfate Tacrolimus monohydrate Virginiamycin M1 Novobiocin Lysergol

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ethambutol dihydrochloride 1070-11-7 Microbiology/Virology Antibacterial Antibiotic Antifungal Ethambutol Dihydrochloride CL-40881 Ethambutol 2HCl Bacterial Ethambutol Emb Dihydrochloride Emb CL 40881 Inhibitor Emb dihydrochloride CL40881 inhibit inhibitor

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