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Ethynodiol diacetate

Catalog No. T0996 CAS 297-76-7

Synonyms: Ethynodiol acetate, 8080 CB

Ethynodiol diacetate (Ethynodiol acetate) is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.

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Ethynodiol diacetate, CAS 297-76-7

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 58.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.89%

Purity: 99.48%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ethynodiol diacetate (Ethynodiol acetate) is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
In vitro	Daily administration of 75 μg of Norgestrel combined with 150 μg of Ethynodiol diacetate and 7.5 μg of Ethinyl estradiol can downregulate plasma concentrations of high-density lipoprotein cholesterol in cynomolgus monkeys. Additionally, a dosage of 6 mg/kg of Ethynodiol diacetate significantly elevates the levels of 3alpha-hydroxy-5alpha-pregnan-20-one and A-homo-3-oxa-5alpha-pregnane-4,20-dione in the urine of female rats, and markedly increases the weight of the rat's pituitary, liver, and kidneys.
In vivo	In the presence of an S9 mix, treatment with NDGA inhibits the genotoxic damage induced by Ethynodiol diacetate, which may be attributed to the suppression of cytochrome P450s that prevent the metabolic activation of Ethynodiol diacetate, or due to NDGA's radical scavenging properties. Concurrently, 150 μg/mL Ethynodiol diacetate increases the rate of sister chromatid exchanges and the frequency of chromosomal aberrations in human lymphocytes, and inhibits lymphocyte proliferation. Notably, < 1.5 μM NDGA can reduce the rate of sister chromatid exchanges in human lymphocytes treated with 150 μg/mL Ethynodiol diacetate.

Synonyms	Ethynodiol acetate, 8080 CB
Molecular Weight	384.51
Formula	C24H32O4
CAS No.	297-76-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 39 mg/mL (101.43 mM)

References and Literature

1. Siddique YH, et al. J Environ Biol, 2007, 28(2), 279-282. 2. Siddique YH, et al. Current Science, 2004, 86(8), 1161-1165. 3. Simic B, et al. Endocr Regul, 1998, 32(3), 125-131. 4. Clarkson TB, et al. Obstet Gynecol, 1990, 75(2), 217-222. 5. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks[J]. Chemical Science. 2020, 11(7): 1775-1797.

Citations

1. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks. Chemical Science. 2020, 11(7): 1775-1797.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library NO PAINS Compound Library FDA-Approved Drug Library Covalent Inhibitor Library Bioactive Compounds Library Max Endocrinology-Hormone Compound Library FDA-Approved & Pharmacopeia Drug Library Nuclear Receptor Compound Library Human Metabolite Library ReFRAME Related Library

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Keywords

Ethynodiol diacetate 297-76-7 Endocrinology/Hormones Others Estrogen/progestogen Receptor Progesterone Receptor NR3C3 Inhibitor Ethynodiol acetate Ethynodiol Diacetate Ethynodiol Acetate 8080 CB inhibit Ethynodiol inhibitor

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