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Endocrinology/Hormones Estrogen/progestogen Receptor Ethynodiol diacetate

Ethynodiol diacetate

Catalog No. T0996   CAS 297-76-7
Synonyms: Ethynodiol acetate, 8080 CB
Purity 99.48% Datasheet MSDS

Ethynodiol diacetate is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.

Ethynodiol diacetate, CAS 297-76-7
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10 mg In stock 35.00
25 mg In stock 51.00
50 mg Inquiry 73.00
100 mg Inquiry 88.00
200 mg Inquiry 114.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ethynodiol diacetate is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
Targets&IC50 ER,  

Description

Ethynodiol diacetate is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.

Targets&IC50

ER

In Vitro

在S9混合物存在时,NDGA处理会抑制Ethynodiol diacetate 引起的遗传毒性损伤,这可能是通过对细胞色素P450s的抑制实现的,而P450s会阻止Ethynodiol diacetate的代谢活化,也可能是由于NDGA具有清除自由基的功能。在S9混合物存在的情况下,150 μg/mL Ethynodiol diacetate会增加人淋巴细胞中姐妹染色单体的交换率和染色体畸变频率并能 抑制淋巴细胞增殖。< 1.5 μM NDGA在150 μg/mL Ethynodiol diacetate处理的人淋巴细胞中可以降低姐妹染色单体的交换率。

In Vivo

每天75 μg Norgestrel和150 μg Ethynodiol diacetate以及7.5 μg Ethinyl estradiol联用可以下调食蟹猴高密度脂蛋白胆固醇的血浆浓度。每天6 mg/kg Ethynodiol diacetate 可以明显增加雌性大鼠尿液中3alpha-hydroxy-5alpha-pregnan-20-one 和A-homo-3-oxa-5alpha-pregnane-4,20-dione的含量,也可以明显增加大鼠脑垂体、肝脏和肾脏的重量。

Synonyms Ethynodiol acetate, 8080 CB
Purity 99.48%
Appearance solid
Molecular Weight 384.51
Formula C24H32O4
CAS No. 297-76-7

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 39 mg/mL (101.43 mM)

Water: 71 mg/mL (184.7 mM)

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Siddique YH, et al. J Environ Biol, 2007, 28(2), 279-282. 2. Siddique YH, et al. Current Science, 2004, 86(8), 1161-1165. 3. Simic B, et al. Endocr Regul, 1998, 32(3), 125-131. 4. Clarkson TB, et al. Obstet Gynecol, 1990, 75(2), 217-222.

Related Compound Libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Endocrinology-Hormones Library FDA-approved Drug Library GPCR Compound Library

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