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Ethynyl estradiol

Catalog No. T1424 CAS 57-63-6

Synonyms: 17α-Ethynylestradiol, Ethinyl Estradiol

Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.

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Ethynyl estradiol, CAS 57-63-6

Pack Size	Availability	Price/USD
100 mg	In stock	$ 32.00
500 mg	In stock	$ 53.00
1 mL * 10 mM (in DMSO)	In stock	$ 36.00

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Purity: 100%

Purity: 99.46%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.
In vitro	Ethinyl Estradiol increases respiratory chain activity in both cultured rat hepatocytesand HepG2 cells. Ethinyl estradiol is a strong promoter of hepatocarcinogenesis. [1] Ethinyl Estradiol enhances the transcript levels of nuclear genome- and mitochondrial genome-encoded genes and respiratory chain activity in female rat liver, and also inhibits transforming growth factor beta (TGFbeta)-induced apoptosis in cultured liver slices and hepatocytes from female rats. Ethinyl Estradiol increases the transcript levels of the mitochondrial genome-encoded genes cytochrome oxidase subunits I, II, and III in cultured female rathepatocytes. Ethinyl Estradiol significantly increases both the levels of glutathione (reduced [GSH] and oxidized [GSSG] forms) per mg protein in mitochondria and nuclei, while the percentage of total glutathione in the oxidized form is not affected. [2]
In vivo	Ethinyl Estradiol (50 mg/kg/day) increases anogenital distance and reduces pup body weight at postnatal day 2, accelerates the age at vaginal opening, reduces F1 fertility and F2 litter sizes, and induces malformations of the external genitalia (5 mg/kg) in the female Long-Evans rat. [3] Ethinyl Estradiol increases the number of low density lipoprotein (LDL) receptors in livers of rats, thereby producing a profound fall in plasma cholesterol levels. Ethinyl Estradiol exerts the same effect in livers of male and female rabbits and that the increase in receptor number is correlated with a 6- to 8-fold increase in the levels of receptor mRNA. [4]

Synonyms	17α-Ethynylestradiol, Ethinyl Estradiol
Molecular Weight	296.4
Formula	C20H24O2
CAS No.	57-63-6

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (185.6 mM)

Ethanol: 55 mg/mL (185.6 mM)

References and Literature

1. Chen J, et al. Toxicol Sci,1999, 51(2), 224-235. 2. Chen J, et al. Toxicol Sci,2003, 75(2), 271-278. 3. Ryan BC, et al. Toxicol Sci,2010, 114(1), 133-148. 4. Ma PT, et al. Proc Natl Acad Sci U S A,1986, 83(3), 792-796.

Citations

1. Sun H, Su X, Liu Y, et al.Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats.iScience.2023: 108392.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Traditional Chinese Medicine Monomer Library Miao medicine Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Natural Product Library for HTS Approved Drug Library Endocrinology-Hormone Compound Library Human Endogenous Metabolite Compound Library Plus FDA-Approved Drug Library

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Isocurcumenol Erteberel Pipendoxifene hydrochloride Iriflophenone Chrysin Diethylstilbestrol Giredestrant tartrate Estradiol

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Keywords

Ethynyl estradiol 57-63-6 Endocrinology/Hormones Metabolism Endogenous Metabolite Estrogen/progestogen Receptor Estrogen Receptor/ERR Inhibitor Ethynylestradiol inhibit 17alpha-Ethynylestradiol 17a-Ethynylestradiol 17α-Ethynylestradiol Ethinyl Estradiol inhibitor

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