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Etonogestrel

Catalog No. T2567 CAS 54048-10-1

Synonyms: 3-Oxodesogestrel, 3-keto-Desogestrel, Nexplanon, Implanon

Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Etonogestrel, CAS 54048-10-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 82.00
25 mg	In stock	$ 171.00
50 mg	In stock	$ 325.00
100 mg	In stock	$ 483.00
200 mg	In stock	$ 690.00
500 mg	In stock	$ 1,080.00
1 g	In stock	$ 1,450.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.69%

Purity: 99.59%

Biological Description

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Storage & Solubility Information

Description	Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.
In vitro	Etonogestrel induces FKBP51 mRNA and protein expression in cultured HESCs[1].
Kinase Assay	First, 0.5 mL tissue homogenate is diluted with 1 mL water. Then, to this mixture, 2.5 mL ethanol and 1.5 mL chloroform (all reagents chilled) are added and shaken for 1 min at 4°C, then centrifuged. The enzyme activity in the supernatant is determined. The assay mixture contained 1.2 mL sodium pyrophosphate buffer (0.025 M, pH 8.3), 0.1 mL 186 mM phenazine methosulfate (PMS), 0.3 mL 30 mM Nitroblue tetrazolium (NBT), and 0.2 mL of nicotinamide adenine dinucleotide (NADH), and appropriately diluted enzyme preparation and water in a total volume of 3 mL. Reaction is initiated by the addition of NADH. After incubation at 30°C for 90 min, the reaction is stopped by the addition of 1 mL glacial acetic acid. The reaction mixture is stirred vigorously and shaken with 4 mL n-butanol. The intensity of the chromogen in the butanol layer is measured at 560 nm against a butanol blank. A system without enzyme served as control. One unit of enzyme activity is defined as 50% inhibition of NBT reduction in 1 min under the assay conditions.
Cell Research	Thawed HESCs are grown to confluence in basal medium (BM), a phenol red-free 1:1 v/v mix of Dulbecco's MEM/Ham's F-12, with 100U/ml penicillin, 100 μg/ml streptomycin, 0.25 μg/ml fungizone complex supplemented with 10% charcoal-stripped calf serum. Confluent HESCs are incubated in parallel in BM with 0.1% ethanol (vehicle control) or 10 nM E2(estradiol) or E2+100 nM P4(progesterone), or 100 nM of ETO(etonogestrel) or 100 nM of MPA(medroxyprogesterone acetate). After 7 days, the cultures are washed twice with 1X phosphate-buffered saline (PBS) to remove residual serum, then placed in a serum-free defined media (DM) comprising BM plus ITS+ (insulin, transferrin, selenious and linoleic acid) premix, 5 μM of FeSO4, 50 μM of ZnSO4, 1 nM of CuSO4, 20 nM of Na2SeO3 trace elements, 50 μg/ml of ascorbic acid and 50 ng/ml of recombinant epidermal growth factor for 24h. The cultures are washed twice with 1X PBS to remove the residual steroids and DM containing corresponding vehicle control or steroids is added to the cultures for 6h or 24h. At the end of incubation periods, HESCs are washed with ice-cold 1X PBS and stored at ?70°C until used for total RNA and protein extraction.(Only for Reference)

Synonyms	3-Oxodesogestrel, 3-keto-Desogestrel, Nexplanon, Implanon
Molecular Weight	324.46
Formula	C22H28O2
CAS No.	54048-10-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 59 mg/mL(181.8 mM)

Ethanol: 64 mg/mL (197.25 mM)

References and Literature

1. Tasdemir N, et al. Gynecol Endocrinol. 2012, 28(6):463-7. 2. Guzeloglu Kayisli O, et al. PLoS One. 2015, 10(10):e0137855.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library ReFRAME Related Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library NO PAINS Compound Library Anti-Cancer Compound Library FDA-Approved Drug Library Bioactive Compound Library

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Keywords

Etonogestrel 54048-10-1 Endocrinology/Hormones Metabolism Others Endogenous Metabolite Estrogen/progestogen Receptor Progesterone Receptor Estrogen Receptor/ERR endometrial Metabolite stromal FK506-binding protein inhibit Estrogen NR3C3 Contraception Desogestrel 3-Oxodesogestrel 3-keto-Desogestrel progestin FKBP51 Nexplanon Implanon FKBP Inhibitor HESC inhibitor

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