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Eurycomalactone

Catalog No. TN1637   CAS 23062-24-0

Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-induced degradation of IκBα or the phosphorylation of IKKα/β and IκBα.

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Eurycomalactone Chemical Structure
Eurycomalactone, CAS 23062-24-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 172.00
5 mg In stock $ 428.00
10 mg In stock $ 623.00
25 mg In stock $ 969.00
50 mg In stock $ 1,280.00
1 mL * 10 mM (in DMSO) In stock $ 432.00
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Purity: 98.98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-induced degradation of IκBα or the phosphorylation of IKKα/β and IκBα.
Targets&IC50 NF-κB:0.5 μM
In vitro Eurycomalactone (ECL), an active quassinoid isolated from Eurycoma longifolia Jack, has been demonstrated to possess anticancer activity.?ECL exhibited selective cytotoxicity against the NSCLC cells A549 and COR-L23 compared to the normal lung fibroblast.?Clonogenic survival results indicated that ECL treatment prior to irradiation synergistically decreased the A549 and COR-L23 colony number.?ECL treatment reduced the expression of cyclin B1 and CDK1/2 leading to induce cell cycle arrest at the radiosensitive G /M phase.?Moreover, ECL markedly delayed the repair of radiation-induced DNA double-strand breaks (DSBs).?In A549 cells, pretreatment with ECL not only delayed the resolving of radiation-induced γ-H2AX foci but also blocked the formation of 53BP1 foci at the DSB sites.?In addition, ECL pretreatment attenuated the expression of DNA repair proteins Ku-80 and KDM4D in both NSCLC cells.?Consequently, these effects led to an increase in apoptosis in irradiated cells.?Thus, ECL radiosensitized the NSCLC cells to X-ray via G /M arrest induction and delayed the repair of X-ray-induced DSBs. It has?a great potential for ECL as an alternative safer radiosensitizer for increasing the RT efficiency against NSCLC[2].
Source
Molecular Weight 348.39
Formula C19H24O6
CAS No. 23062-24-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (157.87 mM)

TargetMolReferences and Literature

1. Cytotoxic activity of quassinoids from Eurycoma longifolia.Nat Prod Commun. 2010 Jul;5(7):1009-12. 2. Dukaew N , Konishi T , Chairatvit K , et al. Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells through G2/M Cell Cycle Arrest and Delayed DNA Double-strand Break Repair[J]. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2019.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Liver Cancer Compound Library Anti-Ovarian Cancer Compound Library Anti-Pancreatic Cancer Compound Library NF-κB Signaling Compound Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compounds Library Max Selected Plant-Sourced Compound Library Natural Product Library for HTS RO5 Drug-like Natural Product Library

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Keywords

Eurycomalactone 23062-24-0 Microbiology/Virology NF-Κb Anti-infection NF-κB DNA double-strand protein synthesis Inhibitor Nuclear factor-kappaB Nuclear factor-κB cisplatin cyclin D1 inhibit Eurycoma longifolia Jack inhibitor

 

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