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Euscaphic acid

Catalog No. TN1134   CAS 53155-25-2

Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations.

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Euscaphic acid Chemical Structure
Euscaphic acid, CAS 53155-25-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 122.00
5 mg In stock $ 355.00
10 mg In stock $ 527.00
25 mg In stock $ 842.00
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1 mL * 10 mM (in DMSO) In stock $ 393.00
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Purity: 98.93%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations.
Targets&IC50 calf DNA polymerase α:61 μM (IC50), rat DNA polymerase β:108 μM (IC50)
In vitro Isolated aorta was used to test the anti-contraction effects and the possible mode of action(s) of the EA (1*10 -7 M) and (3*10 -7 M) isolated from Crataegus azarolus var. aronia L. Euscaphic acid showed high anti-contraction effects on norepinephrin (NE), (1*10 -9 -10 -4 M) induced contraction in aortic smooth muscle cells in endothelium-intact, endothelium-denuded, and aortic rings pre-incubated with potassium (K + )-channels blocker (tetraethylammonium, TEA), prostaglandin I 2 (PGI ) inhibitor (indomethacin) and cyclic guanosine monophosphate (cGMP) inhibitor ( methylene blue). On the other hand, other K 2 channels subtype blockers glibenclamide (GLIB); barium chloride (BaCl ) and 4-aminopyridine (4-AP) demonstrated that adenosine triphosphate sensitive K + (K ATP ), inwardly rectifying K 2 + (K ir ) and voltage-dependent K ) channels played no role in anti-contraction induced by EA. Furthermore, the role of L-types calcium (Ca ) channels in EA anti-contractile effects on aortic smooth muscle cells was proved, by using the Ca -channel blocker verapamil, as indicated by the production of a potent anti-contraction effect . The results of the current study indicate that the anti-contraction effects of EA may be due to the activation of calcium dependent, K ) channels and blocking of L-type Ca ++ channels.
Source
Molecular Weight 488.7
Formula C30H48O5
CAS No. 53155-25-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (102.31 mM)

TargetMolReferences and Literature

1. Mahmud S A . Anti-Contraction Effects of Euscaphic Acid Isolated from Crataegus azarolus var. aronia L on Rat’s Aortic Smooth Muscle. 2015.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Inflammatory Traditional Chinese Medicine Compound Library Anti-Pancreatic Cancer Compound Library Antiparasitic Natural Product Library Anti-Cancer Metabolism Compound Library Inhibitor Library GPCR Compound Library Bioactive Compound Library Bioactive Compounds Library Max Chinese Pharmacopoeia Natural Product Library Antioxidant Compound Library

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Keywords

Euscaphic acid 53155-25-2 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair GPCR/G Protein Immunology/Inflammation Metabolism PI3K/Akt/mTOR signaling LDL PI3K DNA/RNA Synthesis NO Synthase Prostaglandin Receptor Inhibitor inhibit Phosphoinositide 3-kinase inhibitor

 

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