Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 980.00 | |
5 mg | Inquiry | $ 4,800.00 |
Description | ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP). |
Source |
Molecular Weight | 350.45 |
Formula | C20H30O5 |
CAS No. | 78536-37-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Excisanin A 78536-37-5 Angiogenesis Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair GPCR/G Protein Immunology/Inflammation MAPK NF-Κb PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Prostaglandin Receptor JNK PARP GSK-3 MMP FAK NF-κB Wnt/beta-catenin Akt Caspase PI3K inhibitor inhibit